An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein (Q28589972)

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English	An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein	scientific journal article

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scholarly article

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31 January 2017

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein (English)

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31 January 2017

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GOA release 2020-03-11

Synovial apoptosis inhibitor 1, synoviolin

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GOA release 2020-03-11

Yoshihisa Yamano

7

object named as

Yoshihisa Yamano

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31 January 2017

Naoko Yagishita

6

object named as

Naoko Yagishita

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31 January 2017

8

object named as

Tetsuya Amano

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31 January 2017

author name string

Tomoji Maeda

1

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31 January 2017

Toshihiro Marutani

2

1 reference

31 January 2017

Kun Zou

3

1 reference

31 January 2017

Wataru Araki

4

1 reference

31 January 2017

Chiaki Tanabe

5

1 reference

31 January 2017

Makoto Michikawa

9

1 reference

31 January 2017

Toshihiro Nakajima

10

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31 January 2017

Hiroto Komano

11

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31 January 2017

language of work or name

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publication date

1 October 2009

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31 January 2017

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31 January 2017

276

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31 January 2017

20

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31 January 2017

5832–5840

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31 January 2017

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Proteasome-independent functions of ubiquitin in endocytosis and signaling

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Back to the future with ubiquitin

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Novel role of presenilins in maturation and transport of integrin beta 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

The ubiquitin‐like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid β‐protein generation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Degradation of nicastrin involves both proteasome and lysosome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Cellular localization of Nicastrin affects amyloid beta species production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Essential role of synoviolin in embryogenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

A new functional screening system for identification of regulators for the generation of amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

A family of membrane proteins associated with presenilin expression and γ-secretase function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07264.X

21 January 2018

Identifiers

10.1111/J.1742-4658.2009.07264.X

1 reference

31 January 2017

1 reference

31 January 2017

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