Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway (Q28579883)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0140249

protein catabolic process at synapse

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0140246

regulation protein catabolic process at postsynapse

1 reference

Gene Ontology release 2020-05-02

Gregory D. Salinas

1

1 reference

31 January 2017

Leslie A. C. Blair

2

1 reference

31 January 2017

Leigh A. Needleman

3

1 reference

31 January 2017

Justina D. Gonzales

4

1 reference

31 January 2017

Ying Chen

5

1 reference

31 January 2017

Min Li

6

1 reference

31 January 2017

Jeffrey D. Singer

7

1 reference

31 January 2017

John Marshall

Journal of Biological Chemistry

8

1 reference

31 January 2017

language of work or name

English

0 references

publication date

29 December 2006

1 reference

31 January 2017

1 reference

31 January 2017

281

1 reference

31 January 2017

52

1 reference

31 January 2017

40164–40173

1 reference

31 January 2017

Kainate receptor physiology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Cell Surface Expression of GluR5 Kainate Receptors Is Regulated by an Endoplasmic Reticulum Retention Signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

SAP90 binds and clusters kainate receptors causing incomplete desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

A C-terminal determinant of GluR6 kainate receptor trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

X-chromosome-counting mechanisms that determine nematode sex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

The synaptic activation of kainate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Activity-dependent dynamics and sequestration of proteasomes in dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Protein degradation: CUL-3 and BTB--partners in proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Actinfilin, a brain-specific actin-binding protein in postsynaptic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Experimental observations on the development of polarity by hippocampal neurons in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Ubiquitin and the synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Regulation of nicotinic receptor expression by the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

ER protein quality control and proteasome-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

The BACK domain in BTB-kelch proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Palmitoylation of the GluR6 kainate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Structural requirements for palmitoylation of surfactant protein C precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

A mosaic of functional kainate receptors in hippocampal interneurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200

Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608194200