Glutamate ionotropic receptor NMDA type subunit 1 (Q28562649)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35439

ionotropic glutamate receptor, metazoa

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35439

Transporter Classification Database ID

1.A.10.1.6

retrieved

2 October 2019

hierarchical database ID heuristic

Calmodulin-binding domain C0, NMDA receptor, NR1 subunit, protein family

1 reference

Receptor, ligand binding region, protein family

1 reference

Ionotropic glutamate receptor domain, protein family

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

ionotropic glutamate receptor activity

3 references

14 February 2019

Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

NMDA glutamate receptor activity

9 references

14 February 2019

Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

signaling receptor binding

IBA

1 reference

14 February 2019

Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

13 references

14 February 2019

The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

A novel family of adhesion-like molecules that interacts with the NMDA receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

3 references

14 February 2019

Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

voltage-gated cation channel activity

1 reference

14 February 2019

Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

glutamate receptor binding

IMP

1 reference

14 February 2019

NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

signaling receptor activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

Prenatal development of NMDA receptor composition and function in trigeminal neurons

neurotransmitter binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

protein-containing complex binding

1 reference

14 February 2019

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

protein heterodimerization activity

IPI

1 reference

14 February 2019

Amino terminal domains of the NMDA receptor are organized as local heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

protein dimerization activity

1 reference

14 February 2019

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

integral component of plasma membrane

3 references

14 February 2019

Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

2 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

NMDA selective glutamate receptor complex

8 references

14 February 2019

Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

14 February 2019

Control of excitatory and inhibitory synapse formation by neuroligins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

postsynaptic membrane

1 reference

14 February 2019

1 reference

14 February 2019

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

hippocampal mossy fiber to CA3 synapse

IPI

1 reference

14 February 2019

Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

parallel fiber to Purkinje cell synapse

1 reference

14 February 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

integral component of presynaptic membrane

1 reference

14 February 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

integral component of postsynaptic density membrane

1 reference

14 February 2019

Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

2 references

1 reference

14 February 2019

Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of calcium ion transport into cytosol

TAS

1 reference

14 February 2019

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of cell death

1 reference

14 February 2019

Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

response to organic cyclic compound

1 reference

14 February 2019

Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

ion transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

ionotropic glutamate receptor signaling pathway

1 reference

14 February 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

1 reference

14 February 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

protein tetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

protein heterotetramerization

1 reference

14 February 2019

Crystal structure of a heterotetrameric NMDA receptor ion channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices

response to calcium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

regulation of postsynaptic membrane potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate

response to fungicide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

cellular response to manganese ion

1 reference

14 February 2019

Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

cation transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

regulation of presynaptic membrane potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of Schwann cell migration

1 reference

14 February 2019

Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of dendritic spine maintenance

IMP

1 reference

14 February 2019

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of reactive oxygen species biosynthetic process

1 reference

14 February 2019

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of excitatory postsynaptic potential

1 reference

14 February 2019

Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

positive regulation of cysteine-type endopeptidase activity

1 reference

14 February 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35439

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1.A.10.1.6

2 references

Transporter Classification database

retrieved

13 March 2020