Mitogen activated protein kinase kinase 1 (Q28562571)

membrane proteins

1 reference

inferred from GOA cell component → membrane

Protein kinase domain, protein family

1 reference

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

protein kinase activity

1 reference

14 February 2019

MAP kinase kinase activity

6 references

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

protein serine/threonine/tyrosine kinase activity

IBA

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

protein tyrosine kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Insulin enhances growth hormone induction of the MEK/ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

microtubule organizing center

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

3 references

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Insulin enhances growth hormone induction of the MEK/ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Insulin enhances growth hormone induction of the MEK/ERK signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

2 references

perinuclear region of cytoplasm

1 reference

14 February 2019

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

regulation of vascular associated smooth muscle contraction

1 reference

14 February 2019

Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

protein phosphorylation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

response to oxidative stress

1 reference

14 February 2019

Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

cell population proliferation

1 reference

14 February 2019

Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of autophagy

1 reference

14 February 2019

Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of gene expression

2 references

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

negative regulation of gene expression

1 reference

14 February 2019

MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of cell migration

IBA

1 reference

14 February 2019

MEK/ERK regulates adherens junctions and migration through Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

stress-activated protein kinase signaling cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

activation of protein kinase activity

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Regulation of bidirectional melanosome transport by organelle bound MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

regulation of stress-activated MAPK cascade

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

14 February 2019

Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

negative regulation of homotypic cell-cell adhesion

1 reference

14 February 2019

MEK/ERK regulates adherens junctions and migration through Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

intracellular signal transduction

1 reference

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of GTPase activity

1 reference

14 February 2019

MEK/ERK regulates adherens junctions and migration through Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of muscle contraction

2 references

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of Ras protein signal transduction

1 reference

14 February 2019

The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

vesicle transport along microtubule

1 reference

14 February 2019

Regulation of bidirectional melanosome transport by organelle bound MAP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

1 reference

14 February 2019

Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway

response to axon injury

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

neuron projection morphogenesis

1 reference

14 February 2019

Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

protein heterooligomerization

1 reference

14 February 2019

DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

response to glucocorticoid

IPI

1 reference

14 February 2019

Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy

triglyceride homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

regulation of Golgi inheritance

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

2 references

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

regulation of early endosome to late endosome transport

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

positive regulation of ATP biosynthetic process

2 references

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

14 February 2019

ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01986

has part(s)

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference