Mitogen activated protein kinase 3 (Q28561105)

http://www.ebi.ac.uk/interpro/protein/P21708

mitogen-activated protein (MAP) kinase, ERK1/2

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21708

membrane proteins

1 reference

inferred from GOA cell component → membrane

Protein kinase domain, protein family

1 reference

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

phosphotyrosine residue binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

protein kinase activity

2 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

7 references

14 February 2019

Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

MAP kinase kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

3 references

14 February 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

scaffold protein binding

1 reference

14 February 2019

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

5 references

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

4 references

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

3 references

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

protein-containing complex

1 reference

14 February 2019

Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to DNA damage stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

DNA damage induced protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

response to toxic substance

IDA

1 reference

14 February 2019

MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

animal organ morphogenesis

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of gene expression

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of macrophage chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

neural crest cell development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

2 references

peptidyl-serine phosphorylation

1 reference

14 February 2019

Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

sensory perception of pain

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

arachidonic acid metabolic process

1 reference

14 February 2019

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of ossification

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

BMP signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of cellular pH

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

thyroid gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of cyclase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

lipopolysaccharide-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of telomere maintenance via telomerase

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of stress-activated MAPK cascade

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to amino acid starvation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to reactive oxygen species

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of histone acetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

intracellular signal transduction

3 references

14 February 2019

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

peptidyl-tyrosine autophosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

outer ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

response to exogenous dsRNA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of translation

1 reference

14 February 2019

Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

Ovarian steroid receptors and activated MAPK in the regional decidualization in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cartilage development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

stress-activated MAPK cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of cytoskeleton organization

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of telomerase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

Bergmann glial cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cardiac neural crest cell development involved in heart development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

protein-containing complex assembly

1 reference

14 February 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

interleukin-1-mediated signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to organic substance

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to tumor necrosis factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

caveolin-mediated endocytosis

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of Golgi inheritance

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

cellular response to dopamine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of telomere capping

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of xenophagy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

positive regulation of metallopeptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

regulation of early endosome to late endosome transport

1 reference

14 February 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708

negative regulation of apolipoprotein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21708