High mobility group box 1 (Q28560462)

http://www.ebi.ac.uk/interpro/protein/P63159

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

High mobility group box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HMG box A DNA-binding domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

four-way junction DNA binding

1 reference

9 May 2019

The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

open form four-way junction DNA binding

1 reference

9 May 2019

A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

crossed form four-way junction DNA binding

1 reference

9 May 2019

A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

double-stranded DNA binding

1 reference

9 May 2019

DNA binding by single HMG box model proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

single-stranded DNA binding

1 reference

9 May 2019

DNA binding by single HMG box model proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Interactions of recombinant HMGB proteins with branched RNA substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

3 references

9 May 2019

30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

protein dimerization activity

1 reference

9 May 2019

The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

RAGE receptor binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

supercoiled DNA binding

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

endoplasmic reticulum-Golgi intermediate compartment

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of mesenchymal cell proliferation

1 reference

9 May 2019

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

activation of innate immune response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

adaptive immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

immune system process

1 reference

9 May 2019

regulation of T cell mediated immune response to tumor cell

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

inflammatory response

1 reference

9 May 2019

cellular response to DNA damage stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

nervous system development

1 reference

9 May 2019

30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

negative regulation of DNA replication

1 reference

9 May 2019

HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of cell population proliferation

1 reference

9 May 2019

High-mobility group box 1 protein activates hepatic stellate cells in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

regulation of signaling receptor activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of cell death

1 reference

9 May 2019

Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of neuron projection development

1 reference

9 May 2019

Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of smooth muscle cell migration

1 reference

9 May 2019

The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of cell migration

1 reference

9 May 2019

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

neuron projection development

1 reference

9 May 2019

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

actin cytoskeleton reorganization

IGI

1 reference

9 May 2019

The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

response to lipopolysaccharide

1 reference

9 May 2019

The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

developmental process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of interleukin-1 production

1 reference

9 May 2019

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of interleukin-6 production

3 references

9 May 2019

Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of interleukin-8 production

1 reference

9 May 2019

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of tumor necrosis factor production

3 references

9 May 2019

Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Insulin attenuates the systemic inflammatory response in endotoxemic rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of myeloid cell apoptotic process

1 reference

9 May 2019

Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of toll-like receptor 9 signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

response to interferon-gamma

ISS

1 reference

9 May 2019

Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of apoptotic process

1 reference

9 May 2019

The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in viv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

apoptotic cell clearance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

ISS

innate immune response

1 reference

9 May 2019

positive regulation of innate immune response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of myoblast differentiation

1 reference

9 May 2019

Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of mitotic cell cycle

1 reference

9 May 2019

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

regulation of inflammatory response

1 reference

9 May 2019

Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

male-specific defense response to bacterium

1 reference

9 May 2019

The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

induction of positive chemotaxis

1 reference

9 May 2019

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of DNA ligation

1 reference

9 May 2019

HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in viv

myoblast proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

cellular response to interleukin-1

1 reference

9 May 2019

Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of macrophage inflammatory protein 1 alpha production

1 reference

9 May 2019

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

positive regulation of NIK/NF-kappaB signaling

ISS

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159

High mobility group box domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63159

HMG box A DNA-binding domain, conserved site

1 reference

stated in

InterPro Release 71.0