Neurotrophic receptor tyrosine kinase 2 (Q28559477)

Immunoglobulin-like fold

1 reference

Protein kinase-like domain superfamily

1 reference

tyrosine-protein kinase, neurotrophic receptor, type 2

1 reference

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin I-set, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Leucine-rich repeat N-terminal domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

Tyrosine-protein kinase, receptor class II, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

protein kinase activity

1 reference

14 February 2019

transmembrane receptor protein serine/threonine kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

protein tyrosine kinase activity

TAS

transmembrane receptor protein tyrosine kinase activity

TAS

3 references

4 references

14 February 2019

Rapid activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway by electroconvulsive shock in the rat prefrontal cortex is not associated with TrkB neurotrophin receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

neurotrophin receptor activity

4 references

14 February 2019

Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

7 references

14 February 2019

Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

receptor tyrosine kinase binding

1 reference

14 February 2019

TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

protein homodimerization activity

IPI

1 reference

14 February 2019

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

brain-derived neurotrophic factor binding

4 references

14 February 2019

Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

brain-derived neurotrophic factor-activated receptor activity

3 references

14 February 2019

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

rough endoplasmic reticulum

1 reference

14 February 2019

Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

integral component of plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

3 references

14 February 2019

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

2 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

early endosome membrane

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

3 references

14 February 2019

Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

presynaptic active zone

1 reference

14 February 2019

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

protein phosphorylation

1 reference

14 February 2019

Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of cell population proliferation

1 reference

14 February 2019

Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

response to light stimulus

1 reference

14 February 2019

Temporal and spatial differences in expression of TrkB isoforms in rat retina during constant light exposure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

response to auditory stimulus

1 reference

14 February 2019

Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

central nervous system neuron development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

cerebral cortex development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

neuron differentiation

1 reference

14 February 2019

brain-derived neurotrophic factor receptor signaling pathway

3 references

14 February 2019

Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

14 February 2019

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

neurotrophin signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

regulation of GTPase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

negative regulation of neuron apoptotic process

1 reference

14 February 2019

The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

protein autophosphorylation

regulation of neurotransmitter secretion

2 references

1 reference

14 February 2019

Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of axonogenesis

1 reference

14 February 2019

The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

regulation of dendrite development

1 reference

14 February 2019

Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

regulation of protein kinase B signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of synaptic transmission, glutamatergic

1 reference

14 February 2019

Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

positive regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

cellular response to tumor necrosis factor

1 reference

14 February 2019

Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

trans-synaptic signaling by neuropeptide, modulating synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

cellular response to brain-derived neurotrophic factor stimulus

positive regulation of glucocorticoid receptor signaling pathway

1 reference

14 February 2019

Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63604

tyrosine-protein kinase, active site

IGI

has part(s)

1 reference

immunoglobulin I-set

1 reference

leucine-rich repeat N-terminal domain

1 reference

cysteine-rich flanking region, C-terminal

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin subtype

1 reference

immunoglobulin-like domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, receptor class II, conserved site

1 reference

protein kinase domain

1 reference

Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain

1 reference

Leucine-rich repeat

1 reference