Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells (Q28540339)

11

object named as

Robert Z Orlowski

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author name string

Xin-Yan Pei

1

0 references

Yun Dai

2

0 references

Jessica Felthousen

3

0 references

Shuang Chen

4

0 references

Liang Zhou

6

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Leena E Youssefian

7

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Michael W Sanderson

8

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Wesley W Bodie

9

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Lora B Kramer

10

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Steven Grant

Creative Commons Attribution 4.0 International

12

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language of work or name

English

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publication date

2014

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published in

PLOS One

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volume

9

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issue

3

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page(s)

e89064

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copyright license

start time

4 March 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

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29 September 2017

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Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

29 September 2017

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A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

29 September 2017

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Myeloid cell factor-1 is a critical survival factor for multiple myeloma

29 September 2017

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29 September 2017

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29 September 2017

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3 June 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

3 June 2018

1 reference

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Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

3 June 2018

1 reference

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Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

21 January 2018

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Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

IL-6-independent expression of Mcl-1 in human multiple myeloma.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0089064

Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24594907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Management of relapsed and relapsed/refractory multiple myeloma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24594907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24594907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0089064

1 reference

3914666

ADS bibcode

2014PLoSO...989064P

0 references

3914666

1 reference

1 reference

1 reference