Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons (Q28510512)

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10 March 2020

title

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons (English)

2 references

25 January 2017

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10 March 2020

0 references

1 reference

GOA release 2020-03-11

Interferon regulatory factor 7

1 reference

TNF receptor-associated factor 6

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Mark Mellett

3

1 reference

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10 March 2020

Bingwei Wang

6

1 reference

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10 March 2020

John J Callanan

8

1 reference

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10 March 2020

Bernard P. Mahon

9

1 reference

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10 March 2020

Paul N Moynagh

10

1 reference

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10 March 2020

1

Jakub Siednienko

2 references

25 January 2017

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10 March 2020

author name string

Ruaidhri Jackson

2

2 references

25 January 2017

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10 March 2020

Nezira Delagic

4

2 references

25 January 2017

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10 March 2020

Shuo Yang

5

2 references

25 January 2017

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10 March 2020

Lisa S Tang

7

1 reference

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10 March 2020

language of work or name

English

0 references

publication date

7 October 2012

1 reference

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10 March 2020

2 references

25 January 2017

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10 March 2020

volume

13

2 references

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10 March 2020

issue

11

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25 January 2017

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10 March 2020

page(s)

1055-1062

1 reference

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

10 March 2020

cites work

1 reference

TRAF6 is a signal transducer for interleukin-1

21 April 2017

1 reference

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 April 2017

1 reference

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 April 2017

1 reference

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

21 April 2017

1 reference

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

21 April 2017

1 reference

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 April 2017

1 reference

Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1

21 April 2017

1 reference

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

21 April 2017

1 reference

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

21 April 2017

1 reference

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

21 April 2017

1 reference

Pellino2 activates the mitogen activated protein kinase pathway

21 April 2017

1 reference

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

21 April 2017

1 reference

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 April 2017

1 reference

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL

21 April 2017

1 reference

Direct activation of protein kinases by unanchored polyubiquitin chains

21 April 2017

1 reference

Type I interferons in host defense

21 April 2017

1 reference

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

21 April 2017

1 reference

Ubiquitin signalling in the NF-kappaB pathway

21 April 2017

1 reference

TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

21 April 2017

1 reference

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

21 January 2018

1 reference

21 January 2018

The NF-kappaB pathway

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

21 January 2018

1 reference

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

1 reference

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

21 January 2018

1 reference

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

21 January 2018

1 reference

Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

21 January 2018

1 reference

Type I interferons (alpha/beta) in immunity and autoimmunity

21 January 2018

1 reference

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

21 January 2018

1 reference

Pellino proteins: novel players in TLR and IL-1R signalling

21 January 2018

1 reference

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases

21 January 2018

1 reference

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

21 January 2018

1 reference

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.

21 January 2018

1 reference

The role of TBK1 and IKKε in the expression and activation of Pellino 1.

21 January 2018

1 reference

Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.

21 January 2018

1 reference

Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

21 January 2018

1 reference

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

21 January 2018

1 reference

Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner

21 January 2018

1 reference

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

21 January 2018

1 reference

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

21 January 2018

1 reference

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1

21 January 2018

1 reference

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

21 January 2018

1 reference

Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor

21 January 2018

1 reference

Interferons in autoimmune and inflammatory diseases: regulation and roles

21 January 2018

1 reference

The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner

21 January 2018

1 reference

Mal mediates TLR-induced activation of CREB and expression of IL-10.

21 January 2018

1 reference

The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23042151

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23042151

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Peli1 (rel)ieves autoimmunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23042151

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2429

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23042151%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23042151%20AND%20SRC:MED&resulttype=core&format=json