Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex (Q28505970)

Epidermal growth factor receptor pathway substrate 8

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Pier Paolo Di Fiore

10

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Emanuela Frittoli

5

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Silke Gerboth

4

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Giorgio Scita

13

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Andrea Disanza

1

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Francesca Milanesi

9

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Maud Hertzog

3

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author name string

Sara Mantoani

2

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24 January 2017

Anika Steffen

6

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24 January 2017

Kerstin Berhoerster

7

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24 January 2017

Hans-Juergen Kreienkamp

8

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24 January 2017

Andrea Ciliberto

11

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24 January 2017

Theresia E. B. Stradal

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

12

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24 January 2017

1 December 2006

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24 January 2017

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24 January 2017

8

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24 January 2017

12

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24 January 2017

1337–1347

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24 January 2017

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A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein

21 April 2017

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Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

21 April 2017

1 reference

Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation

21 April 2017

1 reference

Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases

21 April 2017

1 reference

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

21 April 2017

1 reference

Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

21 April 2017

1 reference

IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness

21 April 2017

1 reference

EPS8 and E3B1 transduce signals from Ras to Rac

21 April 2017

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Eps8 controls actin-based motility by capping the barbed ends of actin filaments

21 April 2017

1 reference

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway

21 April 2017

1 reference

Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2

21 April 2017

1 reference

The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia

21 April 2017

1 reference

WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac

21 April 2017

1 reference

Structure and function of the feed-forward loop network motif

21 April 2017

1 reference

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

21 April 2017

1 reference

Mechanism of filopodia initiation by reorganization of a dendritic network

21 April 2017

1 reference

Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

21 April 2017

1 reference

The cytoskeleton, cellular motility and the reductionist agenda.

21 April 2017

1 reference

7 January 2021

Mechanism of actin-based motility.

1 reference

7 January 2021

Why are two different cross-linkers necessary for actin bundle formation in vivo and what does each cross-link contribute?

1 reference

7 January 2021

How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response.

1 reference

7 January 2021

Micromechanics and ultrastructure of actin filament networks crosslinked by human fascin: a comparison with alpha-actinin.

1 reference

7 January 2021

The co-workers of actin filaments: from cell structures to signals

1 reference

7 January 2021

The making of filopodia

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7 January 2021

Do filopodia enable the growth cone to find its way?

1 reference

7 January 2021

The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation

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7 January 2021

Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis

1 reference

7 January 2021

Control of the assembly of ATP- and ADP-actin by formins and profilin.

1 reference

7 January 2021

Formins coming into focus

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7 January 2021

The physics of filopodial protrusion

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7 January 2021

Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase

1 reference

7 January 2021

IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena

1 reference

7 January 2021

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

1 reference

7 January 2021

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

1 reference

7 January 2021

Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement

1 reference

7 January 2021

A novel peptide-SH3 interaction.

1 reference

7 January 2021

VASP dynamics during lamellipodia protrusion

1 reference

7 January 2021

How VASP enhances actin-based motility

1 reference

7 January 2021

1 reference

7 January 2021

Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.

1 reference

7 January 2021

Negative regulation of fibroblast motility by Ena/VASP proteins

1 reference

7 January 2021

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

1 reference

7 January 2021

F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling

1 reference

7 January 2021

Functional synergy of actin filament cross-linking proteins

1 reference

7 January 2021

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

1 reference

7 January 2021