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Epidermal growth factor receptor pathway substrate 8 (Q21498751)

From Wikidata
mammalian protein found in Mus musculus
  • epidermal growth factor receptor kinase substrate 8
  • Eps8
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    English
    Epidermal growth factor receptor pathway substrate 8
    mammalian protein found in Mus musculus
    • epidermal growth factor receptor kinase substrate 8
    • Eps8

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    12 references
    retrieved
    14 February 2019
    stated in
    An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Eps8 controls actin-based motility by capping the barbed ends of actin filaments
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    retrieved
    14 February 2019
    stated in
    IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IPI
    actin binding
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IEA
    retrieved
    14 February 2019
    stated in
    Eps8 controls actin-based motility by capping the barbed ends of actin filaments
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping
    GOA
    curator
    UniProt
    UniProt protein ID
    Q08509
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IDA
    retrieved
    14 February 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509
    determination method or standard
    IBA
    cell component
    biological process

    Identifiers

     
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