Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing (Q28504723)

24 January 2017

title

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing (English)

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U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

24 January 2017

main subject

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Growth factor independent 1 transcription repressor

GOA release 2020-03-11

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U2 small nuclear RNA auxiliary factor 1-like 4

GOA release 2020-03-11

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alternative mRNA splicing, via spliceosome

GOA release 2020-03-11

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3

Tarik Möröy

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24 January 2017

Florian Heyd

1

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24 January 2017

Gerdy ten Dam

series ordinal

2

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24 January 2017

language of work or name

English

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publication date

1 August 2006

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24 January 2017

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24 January 2017

volume

7

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24 January 2017

issue

8

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24 January 2017

page(s)

859–867

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24995813

Mechanisms of alternative pre-messenger RNA splicing

31 January 2017

24 January 2017

cites work

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Sex, AGility, and the regulation of alternative splicing

21 April 2017

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The role of U2AF35 and U2AF65 in enhancer-dependent splicing

21 April 2017

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

21 April 2017

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Positive and negative regulation of T-cell activation through kinases and phosphatases

21 April 2017

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CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

21 April 2017

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Alternative pre-mRNA splicing: the logic of combinatorial control

21 April 2017

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Consequences of regulated pre-mRNA splicing in the immune system

21 April 2017

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Multiple links between transcription and splicing

21 January 2018

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Characterization of U2AF(6), a splicing factor related to U2AF(35).

21 January 2018

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Functional recognition of the 3' splice site AG by the splicing factor U2AF35.

21 January 2018

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CD45: a critical regulator of signaling thresholds in immune cells

21 January 2018

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Regulation of Alternative Splicing of CD45 by Antagonistic Effects of SR Protein Splicing Factors

21 January 2018

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Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice

21 January 2018

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Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation

21 January 2018

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A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.

21 January 2018

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Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

21 January 2018

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High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

21 January 2018

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Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development.

21 January 2018

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The zinc finger transcription factor Growth factor independence 1 (Gfi1).

21 January 2018

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The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

21 January 2018

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Alternative splicing of CD45 pre-mRNA is uniquely obedient to conditions in lymphoid cells

21 January 2018

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Dual function for U2AF(35) in AG-dependent pre-mRNA splicing

21 January 2018

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HnRNP L represses exon splicing via a regulated exonic splicing silencer

21 January 2018

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Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons

21 January 2018

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An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

21 January 2018

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Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation

21 January 2018

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Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction

21 January 2018

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Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice

21 January 2018

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CD45 isoforms in T cell signalling and development

21 January 2018

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A point mutation in PTPRC is associated with the development of multiple sclerosis

21 January 2018

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CD45: new jobs for an old acquaintance

21 January 2018

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7 January 2021

Detection of CD45iota mRNA in murine Th1 but not Th2 clones

1 reference

7 January 2021

Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

1 reference

7 January 2021

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

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7 January 2021

Identifiers

DOI

10.1038/NI1361

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