Consequences of regulated pre-mRNA splicing in the immune system (Q35968460)

11 August 2017

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title

Consequences of regulated pre-mRNA splicing in the immune system (English)

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11 August 2017

Kristen W Lynch

1

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11 August 2017

1 December 2004

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Nature Reviews Immunology

11 August 2017

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11 August 2017

4

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11 August 2017

931-940

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11 August 2017

12

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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

11 August 2017

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Mechanisms of alternative pre-messenger RNA splicing

21 January 2018

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Alternative pre-mRNA splicing: the logic of combinatorial control

21 January 2018

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Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology

21 January 2018

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Alternative splicing: increasing diversity in the proteomic world

21 January 2018

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Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay

21 January 2018

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Splice variant in TCRζ links T cell receptor signaling to a G-protein-related signaling pathway

21 January 2018

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Generation of a variant of human interleukin-4 by alternative splicing

21 January 2018

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A native soluble form of CTLA-4

21 January 2018

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A conserved signal-responsive sequence mediates activation-induced alternative splicing of CD45.

21 January 2018

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Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells

21 January 2018

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Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn

21 January 2018

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The exon 7-spliced Lck isoform in T lymphocytes: a potential regulator of p56lck signaling pathways

21 January 2018

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

21 January 2018

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Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812).

21 January 2018

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A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

21 January 2018

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Expression pattern of alternatively spliced PECAM-1 isoforms in hematopoietic cells and platelets

21 January 2018

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ICAM‐1 isoforms: specific activity and sensitivity to cleavage by leukocyte elastase and cathepsin G

21 January 2018

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Modulation of PECAM-1 expression and alternative splicing during differentiation and activation of hematopoietic cells

21 January 2018

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CD44: from adhesion molecules to signalling regulators

21 January 2018

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A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

21 January 2018

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Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator

21 January 2018

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Alternative splice variants of cytokines: making a list

21 January 2018

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Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

21 January 2018

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Solution structure of recombinant human interleukin-6

21 January 2018

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1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling

21 January 2018

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Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor

21 January 2018

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Molecular model of an alternative splice variant of human IL-4, IL-4 delta 2, a naturally occurring inhibitor of IL-4-stimulated T cell proliferation.

21 January 2018

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Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily

21 January 2018

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Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha

21 January 2018

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Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways

21 January 2018

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Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling.

21 January 2018

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IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

21 January 2018

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

21 January 2018

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

21 January 2018

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Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

21 January 2018

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Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

21 January 2018

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Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

21 January 2018

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A point mutation in PTPRC is associated with the development of multiple sclerosis

21 January 2018

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CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

21 January 2018

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Pre-mRNA splicing and human disease

21 January 2018

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Listening to silence and understanding nonsense: exonic mutations that affect splicing

21 January 2018

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Genomic variants in exons and introns: identifying the splicing spoilers

21 January 2018

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

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The soluble interleukin 6 receptor: mechanisms of production and implications in disease

21 January 2018

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Expression analysis and characterization of alternatively spliced transcripts of human IL-7Ralpha chain encoding two truncated receptor proteins in relapsed childhood all.

21 January 2018

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Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice-silencing complex controlled by oncogenic signaling pathways

21 January 2018

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Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway

21 January 2018

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Signal-dependent regulation of splicing via phosphorylation of Sam68

21 January 2018

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The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4.

21 January 2018

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Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72.

21 January 2018

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A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer

21 January 2018

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TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells

21 January 2018

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Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation

21 January 2018

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Exon recognition in vertebrate splicing

21 January 2018

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Alternative pre-mRNA splicing and regulation of programmed cell death.

21 January 2018

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Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens

31 March 2020

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Identification and characterization of two alternative splice variants of human interleukin-2

31 March 2020

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CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development

31 March 2020

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Participation in normal immune responses of a metastasis-inducing splice variant of CD44

31 March 2020

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Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing.

31 March 2020

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CD44 isoforms are differentially regulated in plasma cell dyscrasias and CD44v9 represents a new independent prognostic parameter in multiple myeloma

31 March 2020

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Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling

31 March 2020

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Molecular models of two competitive inhibitors, IL-2delta2 and IL-2delta3, generated by alternative splicing of human interleukin-2

31 March 2020

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Characterization of the membrane-bound and a soluble form of human IL-4 receptor alpha produced by alternative splicing

31 March 2020

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Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

31 March 2020

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IRAK: a kinase associated with the interleukin-1 receptor

31 March 2020

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A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.

31 March 2020

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

31 March 2020

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Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease

31 March 2020

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IL-5 and IL-5 receptor in asthma.

31 March 2020

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A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1497

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11 August 2017

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PubMed ID

15573128