Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef (Q28478210)

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2 February 2020

title

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef (English)

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2 February 2020

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4

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2 February 2020

Oliver T Fackler

5

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2 February 2020

Matthias Geyer

6

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2 February 2020

author name string

Sebastian Breuer

1

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2 February 2020

Simone I Schievink

2

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2 February 2020

Antje Schulte

3

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2 February 2020

language of work or name

English

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publication date

20 May 2011

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2 February 2020

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2 February 2020

volume

6

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2 February 2020

page(s)

e20033

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issue

5

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Creative Commons Attribution 4.0 International

2 February 2020

copyright license

start time

20 May 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

19 March 2017

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

19 March 2017

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

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A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

19 March 2017

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The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

19 March 2017

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Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

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29 September 2017

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Effect of lentivirus encoding HIV-1 Nef-U3 shRNA on the function of HIV-specific memory CD4(+) T cells in patients with chronic HIV-1 infection

29 September 2017

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29 September 2017

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HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

29 September 2017

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29 September 2017

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Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

29 September 2017

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Role of Nef in primate lentiviral immunopathogenesis

29 September 2017

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A cell-penetrating helical peptide as a potential HIV-1 inhibitor

29 September 2017

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Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

29 September 2017

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29 September 2017

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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

29 September 2017

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Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

29 September 2017

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Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

29 September 2017

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HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription

29 September 2017

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Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

29 September 2017

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Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways

29 September 2017

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Functional characterization of HIV-1 Nef mutants in the context of viral infection

29 September 2017

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A peptide inhibitor of HIV-1 assembly in vitro

29 September 2017

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Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef

29 September 2017

1 reference

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Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.

29 September 2017

1 reference

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Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.

29 September 2017

1 reference

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Protein design of an HIV-1 entry inhibitor

29 September 2017

1 reference

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SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

Refined solution structure and backbone dynamics of HIV-1 Nef.

29 September 2017

1 reference

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

Tetherin: Holding On and Letting Go

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020033

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098852

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21625496

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0020033

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625496%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625496%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference