Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis (Q28477245)

2

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David E Garlick

3

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Krista Penta

4

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Andrew R Tapper

5

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Hayla K Sluss

Creative Commons Attribution 4.0 International

6

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language of work or name

English

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publication date

2011

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published in

PLOS One

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volume

6

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issue

9

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page(s)

e24813

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copyright license

start time

27 September 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis

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Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis

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Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice

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Mantle cell lymphoma is characterized by inactivation of the ATM gene

29 September 2017

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Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

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ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer

29 September 2017

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Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia.

29 September 2017

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Biallelic mutations in the ATM gene in T-prolymphocytic leukemia

29 September 2017

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Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia

29 September 2017

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29 September 2017

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Dual roles of ATM in the cellular response to radiation and in cell growth control.

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The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression

21 January 2018

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Tumor suppression by p53 in the absence of Atm.

21 January 2018

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Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

21 January 2018

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Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.

21 January 2018

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Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.

21 January 2018

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ATM mutations in B-cell chronic lymphocytic leukemia.

27 November 2018

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

27 November 2018

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Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21980358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21980358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21980358