Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog (Q28474631)

April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2890405/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

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GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor

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Differential range and activity of various forms of the Hedgehog protein

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The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p

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Lipoprotein particles are required for Hedgehog and Wingless signalling

19 March 2017

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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

19 March 2017

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Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location

19 March 2017

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Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences

19 March 2017

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ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane

19 March 2017

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A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

19 March 2017

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Identification of a palmitic acid-modified form of human Sonic hedgehog

19 March 2017

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Cholesterol modification of hedgehog signaling proteins in animal development

19 March 2017

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The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing

19 March 2017

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Autoproteolysis in hedgehog protein biogenesis

19 March 2017

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

19 March 2017

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Wnt proteins are lipid-modified and can act as stem cell growth factors

7 April 2017

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Developmental roles and clinical significance of hedgehog signaling

7 April 2017

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Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

7 April 2017

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Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

29 September 2017

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Patched, the receptor of Hedgehog, is a lipoprotein receptor

29 September 2017

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Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development

29 September 2017

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Novel lipid modifications of secreted protein signals

29 September 2017

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Hedgehog signalling in cancer formation and maintenance

29 September 2017

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Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

29 September 2017

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Sonic hedgehog in the nervous system: functions, modifications and mechanisms

29 September 2017

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Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

29 September 2017

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Enhanced potency of human Sonic hedgehog by hydrophobic modification.

29 September 2017

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Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner

29 September 2017

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A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.

29 September 2017

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The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

2 June 2018

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N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

2 June 2018

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An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

2 June 2018

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Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

21 January 2018

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Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

21 January 2018

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The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain

21 January 2018

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Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.

21 January 2018

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Identification of membrane O-acyltransferase family motifs

21 January 2018

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Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

21 January 2018

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Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

21 January 2018

1 reference

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Iodinated fatty acids as probes for myristate processing and function. Incorporation into pp60v-src

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20585641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and use of iodo-fatty acid analogs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20585641