BACE1 expression and activity: relevance in Alzheimer's disease (Q28307707)

Europe PubMed Central

title

BACE1 expression and activity: relevance in Alzheimer's disease (English)

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Marija Mihailovich

4

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Daniele Zacchetti

object named as

Daniele Zacchetti

1

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Evelina Chieregatti

object named as

Evelina Chieregatti

2

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author name string

Barbara Bettegazzi

3

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Vitor Lino Sousa

5

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Fabio Grohovaz

6

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Jacopo Meldolesi

Neurodegenerative Diseases

7

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language of work or name

English

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publication date

2007

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published in

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volume

4

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page(s)

117-26

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issue

2-3

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cites work

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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1 reference

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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BACE2 functions as an alternative alpha-secretase in cells

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

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Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

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Oxidative stress increases expression and activity of BACE in NT2 neurons

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Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

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Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

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Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

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Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

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Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation

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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

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Human BACE forms dimers and colocalizes with APP.

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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APP processing and synaptic function

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BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

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Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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Relation of plasma lipids to Alzheimer disease and vascular dementia

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

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Phosphorylation regulates intracellular trafficking of beta-secretase

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Maturation and pro-peptide cleavage of beta-secretase

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The conflicting role of brain cholesterol in Alzheimer's disease: lessons from the brain plasminogen system

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