ASPP [corrected] and cancer (Q28299046)

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

Europe PubMed Central

title

ASPP [corrected] and cancer (English)

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author name string

Giuseppe Trigiante

series ordinal

1

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Xin Lu

series ordinal

2

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language of work or name

English

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publication date

March 2006

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published in

Nature Reviews Cancer

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volume

6

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page(s)

217-26

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issue

3

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cites work

1 reference

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

21 January 2018

1 reference

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

21 January 2018

1 reference

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

1 reference

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

21 January 2018

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Apoptosis - the p53 network

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p53 has a direct apoptogenic role at the mitochondria

31 March 2020

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

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Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations

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p53: a heavily dictated dictator of life and death

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

31 March 2020

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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A novel cofactor for p300 that regulates the p53 response

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ASPP proteins specifically stimulate the apoptotic function of p53

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Two cellular proteins that bind to wild-type but not mutant p53

31 March 2020

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Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

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Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

31 March 2020

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Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

31 March 2020

1 reference

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

31 March 2020

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Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor

31 March 2020

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ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis

31 March 2020

1 reference

Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

31 March 2020

1 reference

Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis

31 March 2020

1 reference

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro

31 March 2020

1 reference

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

31 March 2020

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A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice

31 March 2020

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

31 March 2020

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Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing

31 March 2020

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NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2

31 March 2020

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Gene expression changes in response to E2F1 activation.

31 March 2020

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ASPP1 and ASPP2 are new transcriptional targets of E2F

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Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.

31 March 2020

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Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

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Control of ASPP2/(53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function

31 March 2020

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

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ASPP1 and ASPP2: common activators of p53 family members

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53BP2 induces apoptosis through the mitochondrial death pathway

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Of flies and men; p53, a tumour suppressor

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Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans

31 March 2020

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Modulation of mammalian life span by the short isoform of p53.

31 March 2020

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Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

31 March 2020

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Drosophila p53 preserves genomic stability by regulating cell death

31 March 2020

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Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae

31 March 2020

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DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

31 March 2020

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p53 isoforms can regulate p53 transcriptional activity.

31 March 2020

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

31 March 2020

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

31 March 2020

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p63 is a p53 homologue required for limb and epidermal morphogenesis

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31 March 2020

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p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines

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p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis

31 March 2020

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p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma.

31 March 2020

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Abnormal mRNA expression of ASPP members in leukemia cell lines.

31 March 2020

1 reference

ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.

31 March 2020

1 reference

Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53

31 March 2020

1 reference

Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome

31 March 2020

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

31 March 2020

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

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Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins

31 March 2020

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RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1818

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1083768

1042623983

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Fatcat ID

release_qcifkmxzjvhhpgffsb46rel3wm

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1083768

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference