Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012) (Q28288034)

Expert Opinion on Therapeutic Patents

ChEBI release 2020-05-28

3

Mariangela Urbano

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author name string

Edward Roberts

series ordinal

1

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Miguel Guerrero

series ordinal

2

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Hugh Rosen

series ordinal

4

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language of work or name

English

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publication date

July 2013

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published in

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volume

23

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issue

7

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page(s)

817-41

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cites work

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Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors

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Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

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Structural and functional characteristics of S1P receptors.

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A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor

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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor

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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

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G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

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Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin

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Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

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Sphingosine-1-phosphate Signaling in Endothelial Activation

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Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

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Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

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HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

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S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

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Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury

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Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions

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Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza

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Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.

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Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

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Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

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Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

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21 January 2018

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

638254

638254

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference