Fyn: a novel molecular target in cancer (Q28273098)

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

Europe PubMed Central

title

Fyn: a novel molecular target in cancer (English)

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3

Ravi Salgia

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author name string

Yoshihito D Saito

series ordinal

1

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Ana R Jensen

series ordinal

2

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Edwin M Posadas

series ordinal

4

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language of work or name

English

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publication date

1 April 2010

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published in

Cancer

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volume

116

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page(s)

1629-37

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issue

7

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cites work

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization

29 September 2017

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The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration

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Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.

29 September 2017

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Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.

29 September 2017

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Matrix metalloproteinases and tumor metastasis

29 September 2017

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Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge

29 September 2017

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AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

29 September 2017

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Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha

29 September 2017

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Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells

29 September 2017

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The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

29 September 2017

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Structure and regulation of Src family kinases

29 September 2017

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Integrin signalling during tumour progression

29 September 2017

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Tumor metastasis: a new twist on epithelial-mesenchymal transitions

29 September 2017

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Activation of tyrosine kinases in cancer

29 September 2017

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EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

29 September 2017

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29 September 2017

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Acquisition of transforming properties by FYN, a normal SRC-related human gene

29 September 2017

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29 September 2017

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Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells

2 June 2018

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Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model

27 November 2018

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Overcoming imatinib resistance using Src inhibitor CGP76030, Abl inhibitor nilotinib and Abl/Lyn inhibitor INNO-406 in newly established K562 variants with BCR-ABL gene amplification

27 November 2018

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847065

Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847065

Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer

27 November 2018

1 reference

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Alphavbeta6-Fyn signaling promotes oral cancer progression.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847065

Identification of an alternatively spliced isoform of the fyn tyrosine kinase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847065

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

27 November 2018

1 reference

12 December 2020

Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling

1 reference

12 December 2020

Src family kinases are required for prolactin induction of cell proliferation

1 reference

12 December 2020

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

1 reference

12 December 2020

FYN is overexpressed in human prostate cancer

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCNCR.24879

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/CNCR.24879

1 reference

release_aw6duzf7r5cgtl7a3cn56oxsf4

2554606

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/aw6duzf7r5cgtl7a3cn56oxsf4

24 November 2022

mapped directly with Wikidata item

2554606

1 reference

1 reference

1 reference