Assembly, trafficking and function of gamma-secretase (Q28268951)

Europe PubMed Central

title

Assembly, trafficking and function of gamma-secretase (English)

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main subject

gamma-secretase complex

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Gene Ontology release 2020-05-02

2

Christian Haass

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author name string

Christoph Kaether

series ordinal

1

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Harald Steiner

series ordinal

3

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language of work or name

English

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publication date

2006

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published in

Neurodegenerative Diseases

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volume

3

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issue

4-5

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page(s)

275-83

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cites work

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Uncovering gamma-secretase

21 January 2018

1 reference

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

A nine-transmembrane domain topology for presenilin 1

21 January 2018

1 reference

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

21 January 2018

1 reference

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

21 January 2018

1 reference

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

21 January 2018

1 reference

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

21 January 2018

1 reference

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

Presenilins: molecular switches between proteolysis and signal transduction

21 January 2018

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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

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Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

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Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

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Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

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Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

21 January 2018

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A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

21 January 2018

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Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

21 January 2018

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Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

21 January 2018

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

21 January 2018

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Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

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The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

21 January 2018

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The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

21 January 2018

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Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

21 January 2018

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Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

21 January 2018

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Gamma-secretase complex assembly within the early secretory pathway

21 January 2018

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Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes.

21 January 2018

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Presenilin function and gamma-secretase activity

21 January 2018

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Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

21 January 2018

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The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

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Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

21 January 2018

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000095267

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Consolidated OpenCitations Corpus – April 2017

3268294

3268294

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference