Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies (Q28263887)

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Mariko Matsumoto

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Tsutomu Urano

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Ryuichi Hasegawa

Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site

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language of work or name

English

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publication date

2005

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published in

Drug Safety

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volume

28

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issue

8

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page(s)

677-94

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677-694

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cites work

1 reference

12 December 2020

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol

1 reference

12 December 2020

The fate of naringin in humans: A key to grapefruit juice-drug interactions?

1 reference

12 December 2020

Grapefruit juice can increase the plasma concentrations of oral methylprednisolone

1 reference

12 December 2020

Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses

1 reference

12 December 2020

Lack of significant pharmacokinetic interaction between haloperidol and grapefruit juice

1 reference

12 December 2020

Interactions between grapefruit juice and cardiovascular drugs

1 reference

12 December 2020

The flavonoids. A class of semi-essential food components: their role in human nutrition

1 reference

12 December 2020

Citrus fruits — Varieties, chemistry, technology, and quality evaluation. Part II. Chemistry, technology, and quality evaluation. A. Chemistry

1 reference

12 December 2020

Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life

1 reference

12 December 2020

Effect of grapefruit juice intake on etoposide bioavailability

1 reference

12 December 2020

Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation.

1 reference

12 December 2020

Effects of amiodarone and its active metabolite desethylamiodarone on the ventricular defibrillation threshold.

1 reference

12 December 2020

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

1 reference

12 December 2020

Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation

1 reference

12 December 2020

Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients

1 reference

12 December 2020

Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin

1 reference

12 December 2020

Interaction of citrus juices with felodipine and nifedipine

1 reference

12 December 2020

Interaction between grapefruit juice and midazolam in humans.

1 reference

12 December 2020

Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers

1 reference

12 December 2020

Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

1 reference

12 December 2020

Plasma levels of clozapine and desmethylclozapine are unaffected by concomitant ingestion of grapefruit juice

1 reference

12 December 2020

Organic anion-transporting polypeptide (OATP) transporter family and drug disposition

1 reference

12 December 2020

Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

1 reference

12 December 2020

Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam

1 reference

12 December 2020

Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells

1 reference

12 December 2020

Does grapefruit juice increase the bioavailability of orally administered sex steroids?

1 reference

12 December 2020

Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity

1 reference

12 December 2020

Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite

1 reference

12 December 2020

Multidrug-resistance transporters

1 reference

12 December 2020

Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice

1 reference

12 December 2020

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

1 reference

12 December 2020

Influence of grapefruit juice on scopolamine pharmacokinetics and pharmacodynamics in healthy male and female subjects.

1 reference

12 December 2020

Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance

1 reference

12 December 2020

Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo

1 reference

12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

1 reference

12 December 2020

Grapefruit juice has no effect on quinine pharmacokinetics

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics of theophylline in healthy male volunteers.

1 reference

12 December 2020

Effects of grapefruit juice on the pharmacokinetics of sildenafil

1 reference

12 December 2020

Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

1 reference

12 December 2020

Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers

1 reference

12 December 2020

6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect

1 reference

12 December 2020

Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4.

1 reference

12 December 2020

Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics of microemulsion cyclosporine and its metabolite in healthy volunteers: does the formulation difference matter?

1 reference

12 December 2020

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

1 reference

12 December 2020

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

1 reference

12 December 2020

The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study

1 reference

12 December 2020

Inhibition of 17β-estradiol metabolism by grapefruit juice in ovariectomized women

1 reference

12 December 2020

Interaction between grapefruit juice and praziquantel in humans.

1 reference

12 December 2020

6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

1 reference

12 December 2020

Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components

1 reference

12 December 2020

[Excretion and decomposition of 3-methoxy-N-methylmorphinan and its demethylated derivatives in man.]

1 reference

12 December 2020

Regulation and function of the multidrug resistance genes in liver.

1 reference

12 December 2020

Effects of grapefruit juice and smoking on verapamil concentrations in steady state

1 reference

12 December 2020

Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance

1 reference

12 December 2020

Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid

1 reference

12 December 2020

Repeated ingestion of grapefruit juice does not alter clozapine's steady-state plasma levels, effectiveness, and tolerability.

1 reference

12 December 2020

Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects

1 reference

12 December 2020

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

1 reference

12 December 2020

The effects of grapefruit juice on the pharmacokinetics of erythromycin

1 reference

12 December 2020

Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans

1 reference

12 December 2020

Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics

1 reference

12 December 2020

The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers

1 reference

12 December 2020

Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese

1 reference

12 December 2020

Effect of grapefruit juice on clarithromycin pharmacokinetics

1 reference

12 December 2020

Interaction between grapefruit juice and diazepam in humans.

1 reference

12 December 2020

Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174

1 reference

12 December 2020

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

1 reference

12 December 2020

Grapefruit juice increases oral nimodipine bioavailability

1 reference

12 December 2020

Grapefruit juice substantially increases plasma concentrations of buspirone

1 reference

12 December 2020

Absolute bioavailability of digoxin tablets

1 reference

12 December 2020

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.

1 reference

12 December 2020

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

1 reference

12 December 2020

Can grapefruit juice influence ethinylestradiol bioavailability?

1 reference

12 December 2020

Grapefruit juice and drugs. How significant is the interaction?

1 reference

12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

1 reference

12 December 2020

Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine

1 reference

12 December 2020

Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice

1 reference

12 December 2020

Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers

1 reference

12 December 2020

Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.

1 reference

12 December 2020

The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers

1 reference

12 December 2020

Single-dose pharmacokinetics of amprenavir coadministered with grapefruit juice

1 reference

12 December 2020

Grapefruit juice--felodipine interaction in the elderly

1 reference

12 December 2020

Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

1 reference

12 December 2020

Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients

1 reference

12 December 2020

Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy

1 reference

12 December 2020

[Grapefruit juice as a contraindication? An approach in psychiatry]

1 reference

12 December 2020

Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine

1 reference

12 December 2020

Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins

1 reference

12 December 2020

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine

1 reference

12 December 2020

The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice

1 reference

12 December 2020

The effects of fruit juices on drug disposition: a new model for drug interactions

1 reference

12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

1 reference

12 December 2020

Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice

1 reference

12 December 2020

Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

1 reference

12 December 2020

Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone

1 reference

12 December 2020

Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.

1 reference

12 December 2020

Grapefruit juice-drug interactions

1 reference

12 December 2020

Inhibition selectivity of grapefruit juice components on human cytochromes P450

1 reference

12 December 2020

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

1 reference

12 December 2020

Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects

1 reference

12 December 2020

Effect of grapefruit juice on cyclosporin A pharmacokinetics in pediatric renal transplant patients.

1 reference

12 December 2020

Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients.

1 reference

12 December 2020

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

1 reference

12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

12 December 2020

Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers

1 reference

12 December 2020

Dramatic inhibition of amiodarone metabolism induced by grapefruit juice

1 reference

12 December 2020

Identification of products produced by the anaerobic degradation of naringin by Butyrivibrio sp. C3

1 reference

12 December 2020

Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects

1 reference

12 December 2020

The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein

1 reference

12 December 2020

Factors affecting the absolute bioavailability of nifedipine

1 reference

12 December 2020