Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components (Q41596616)

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scientific article published on October 1999

Language	Label	Description	Also known as
English	Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components	scientific article published on October 1999

Statements

scholarly article

1 reference

Europe PubMed Central

4 October 2017

Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components (English)

1 reference

Europe PubMed Central

4 October 2017

1 reference

based on heuristic

inferred from title

author name string

V A Eagling

1

1 reference

Europe PubMed Central

4 October 2017

L Profit

2

1 reference

Europe PubMed Central

4 October 2017

D J Back

3

1 reference

Europe PubMed Central

4 October 2017

language of work or name

0 references

publication date

1 October 1999

1 reference

Europe PubMed Central

4 October 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

4 October 2017

48

1 reference

Europe PubMed Central

4 October 2017

4

1 reference

Europe PubMed Central

4 October 2017

543-552

1 reference

Europe PubMed Central

4 October 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Trough concentrations of cyclosporine in blood following administration with grapefruit juice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

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6 June 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

1 reference

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6 June 2018

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

1 reference

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6 June 2018

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

1 reference

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6 June 2018

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

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6 June 2018

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

1 reference

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6 June 2018

Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

First-pass metabolism of midazolam by the human intestine.

1 reference

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6 June 2018

Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1 reference

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Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

1 reference

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6 June 2018

Multidrug transporter P-glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes: modulation with differentiation stage and during aging

1 reference

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6 June 2018

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

1 reference

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6 June 2018

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Interaction of citrus juices with felodipine and nifedipine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

1 reference

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6 June 2018

Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8+ T cells: a role in cytotoxic effector function

1 reference

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6 June 2018

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

6 June 2018

Interaction between grapefruit juice and midazolam in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2014377

19 August 2018

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction effect of grapefruit juice is maximal after the first glass

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First-pass metabolism of cyclosporin by the gut

1 reference

https://pubmed.ncbi.nlm.nih.gov/10583025

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2125.1999.00052.X

1 reference

Europe PubMed Central

4 October 2017

1 reference

Europe PubMed Central

4 October 2017

1 reference

Europe PubMed Central

4 October 2017

ResearchGate publication ID

0 references

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