InTERTesting association between telomerase, mTOR and phytochemicals (Q28262993)

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 April 2017

1 reference

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer

21 April 2017

1 reference

A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function

21 April 2017

1 reference

Regulation of mTOR and cell growth in response to energy stress by REDD1.

21 April 2017

1 reference

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 April 2017

1 reference

Extension of life-span by introduction of telomerase into normal human cells

21 April 2017

1 reference

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

21 April 2017

1 reference

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 April 2017

1 reference

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 April 2017

1 reference

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 April 2017

1 reference

Specific association of human telomerase activity with immortal cells and cancer

21 April 2017

1 reference

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 April 2017

1 reference

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 April 2017

1 reference

The telomerase reverse transcriptase: components and regulation

21 April 2017

1 reference

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 April 2017

1 reference

Suppression of cap-dependent translation in mitosis

21 April 2017

1 reference

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

21 April 2017

1 reference

Modulation of Akt kinase activity by binding to Hsp90

21 April 2017

1 reference

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin

21 April 2017

1 reference

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 April 2017

1 reference

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 April 2017

1 reference

Human telomerase and its regulation

21 April 2017

1 reference

Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT

21 April 2017

1 reference

Involvement of 14-3-3 proteins in nuclear localization of telomerase

21 April 2017

1 reference

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 April 2017

1 reference

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 April 2017

1 reference

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 April 2017

1 reference

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

21 April 2017

1 reference

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 April 2017

1 reference

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 April 2017

1 reference

Defining the role of mTOR in cancer

21 April 2017

1 reference

Telomeres shorten during ageing of human fibroblasts

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Bidirectional transport of amino acids regulates mTOR and autophagy

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Transcriptional control of human p53-regulated genes

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

A survey of telomerase activity in human cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Molecular mechanisms of translation initiation in eukaryotes

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Akt regulates growth by directly phosphorylating Tsc2

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Curcumin disrupts the Mammalian target of rapamycin-raptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomerase: regulation, function and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Dynamic telomerase gene suppression via network effects of GSK3 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Status of PI3K inhibition and biomarker development in cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Tenets of PTEN tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

21 January 2018

Telomerase and cancer

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Chemopreventive effects of natural dietary compounds on cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Biosynthesis of plant isoprenoids: perspectives for microbial engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The function of terpene natural products in the natural world

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Oral-specific chemical carcinogenesis in mice: an exciting model for cancer prevention and therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Rapamycin for chemoprevention of upper aerodigestive tract cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The end of the (DNA) line

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

How shelterin solves the telomere end-protection problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Targeting telomerase for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

A prospective study of tomato products, lycopene, and prostate cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Green tea compound in chemoprevention of cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Terpenoids and breast cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The role of Hsp90 in protein complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Constitutive telomerase expression promotes mammary carcinomas in aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomere uncapping and alternative lengthening of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomerase in the early detection of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Ribosomal protein S6 kinase from TOP mRNAs to cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The mTOR pathway as a potential target for the development of therapies against neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The essence of senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Reverse transcriptase motifs in the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Tectorigenin and other phytochemicals extracted from leopard lily Belamcanda chinensis affect new and established targets for therapies in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

HIF-1-mediated activation of telomerase in cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

PP2A: the expected tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Protein kinase C modulates telomerase activity in human cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Differentiation linked regulation of telomerase activity by Makorin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Give me a break: how telomeres suppress the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

Correlating telomerase activity levels with human neuroblastoma outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

https://api.crossref.org/works/10.1017%2FERM.2012.1

1 reference

7 January 2021

The dual role of protein kinase C in the regulation of telomerase activity in human lymphocytes

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Origin of Concatemeric T7DNA

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Lycopene inhibits disease progression in patients with benign prostate hyperplasia

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Detection of telomerase activity in prostate needle-biopsy samples.

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Regulation of survivin expression by IGF-1/mTOR signaling

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Competitive PCR to detect eIF4E gene amplification in head and neck cancer

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

hTERT is a critical determinant of telomerase activity in renal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

1 reference

https://api.crossref.org/works/10.1017%2FERM.2012.1

7 January 2021