Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity (Q28260201)

2

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Euy-Myoung Jeong

3

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Harvey A Lardin

4

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Hong Liu

5

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Bindiya G Patel

6

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Domenico M Taglieri

7

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Lianzhi Gu

8

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Praveen Kumar

9

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Narayan Pokhrel

10

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Dewan Zeng

11

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Luiz Belardinelli

12

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Dan Sorescu

13

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R John Solaro

14

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Samuel C Dudley

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

15

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language of work or name

English

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publication date

16 March 2012

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published in

Circulation Research

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volume

110

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issue

6

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page(s)

841-50

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cites work

1 reference

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A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine

29 September 2017

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Irbesartan in patients with heart failure and preserved ejection fraction

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Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure

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Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.

29 September 2017

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Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome

29 September 2017

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Late sodium current inhibition as a new cardioprotective approach

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Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.

29 September 2017

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A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation

29 September 2017

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Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial

29 September 2017

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Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current

29 September 2017

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Functional consequences of sarcomeric protein abnormalities in failing myocardium

29 September 2017

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Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

29 September 2017

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Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury

29 September 2017

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Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure

29 September 2017

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Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic

29 September 2017

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Assessment of diastolic dysfunction. Invasive modalities

29 September 2017

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Physiology of diastolic function and transmitral pressure-flow relations

29 September 2017

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Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae.

29 September 2017

1 reference

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Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling

29 September 2017

1 reference

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Hypoxia increases persistent sodium current in rat ventricular myocytes.

2 June 2018

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Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine

2 June 2018

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Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts

2 June 2018

1 reference

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Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy

27 November 2018

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Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation

27 November 2018

1 reference

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Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction

27 November 2018

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Systolic and diastolic heart failure in the community.

27 November 2018

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Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

27 November 2018

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Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

27 November 2018

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Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes.

27 November 2018

1 reference

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Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart.

27 November 2018

1 reference

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Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium

27 November 2018

1 reference

12 December 2020

Ranolazine attenuates palmitoyl-L-carnitine-induced mechanical and metabolic derangement in the isolated, perfused rat heart

1 reference

12 December 2020

Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem

1 reference

12 December 2020

Effects of the reactive oxygen species hypochlorous acid and hydrogen peroxide on force production and calcium sensitivity of rat cardiac myofilaments

1 reference

12 December 2020

Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease

1 reference

12 December 2020

CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction

1 reference

12 December 2020

A controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional antianginal agents. Ranolazine Study Group

1 reference

12 December 2020

SERCA overexpression reduces hydroxyl radical injury in murine myocardium

1 reference

12 December 2020

10.1161/CIRCRESAHA.111.258251

Identifiers

DOI

1 reference

1829502

1829502

1 reference

1 reference

1 reference