Functional consequences of sarcomeric protein abnormalities in failing myocardium (Q36369931)

13 August 2017

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title

Functional consequences of sarcomeric protein abnormalities in failing myocardium (English)

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13 August 2017

Martin M LeWinter

1

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13 August 2017

1 September 2005

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13 August 2017

Heart Failure Reviews

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13 August 2017

10

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13 August 2017

3

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13 August 2017

249-257

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https://scigraph.springernature.com/pub.10.1007/s10741-005-5254-4

13 August 2017

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Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

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Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle

21 January 2018

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Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy

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Adrenergic control of the force-frequency relation

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Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes

21 January 2018

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12 December 2020

Myofibrillar adenosine triphosphatase activity in congestive heart failure

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12 December 2020

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

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12 December 2020

Regulation of cardiac contractile function by troponin I phosphorylation

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12 December 2020

Increased myothermal economy of isometric force generation in compensated cardiac hypertrophy induced by pulmonary artery constriction in the rabbit. A characterization of heat liberation in normal and hypertrophied right ventricular papillary muscl

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Altered myocardial thin-filament function in the failing Dahl salt-sensitive rat heart: amelioration by endothelin blockade

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Protein kinase A mediated modulation of acto-myosin kinetics

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12 December 2020

Thin-filament-based modulation of contractile performance in human heart failure

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12 December 2020

Role of microtubules in the contractile dysfunction of hypertrophied myocardium

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12 December 2020

Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments

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12 December 2020

Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro

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12 December 2020

Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function

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12 December 2020

Myocardial cross-bridge kinetics in transition to failure in Dahl salt-sensitive rats

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12 December 2020

Mechanoenergetic alterations during the transition from cardiac hypertrophy to failure in Dahl salt-sensitive rats

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12 December 2020

Increased Ca2+-sensitivity of myofibrillar tension in heart failure and its functional implication

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12 December 2020

Myosin from failing and non-failing human ventricles exhibit similar contractile properties

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12 December 2020

Acto-myosin crossbridge kinetics in humans with coronary artery disease: influence of sex and diabetes mellitus.

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12 December 2020

Activation of PKC decreases myocardial O2 consumption and increases contractile efficiency in rats

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12 December 2020

Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

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12 December 2020

R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level

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12 December 2020

Troponin T isoform expression in the normal and failing human left ventricle: a correlation with myofibrillar ATPase activity

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12 December 2020

Alterations in left ventricular mechanics, energetics, and contractile reserve in experimental heart failure

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12 December 2020

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants

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12 December 2020

Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy

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12 December 2020

Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure

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12 December 2020

Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I.

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12 December 2020

Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure

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12 December 2020

Altered expression of troponin T isoforms in mild left ventricular hypertrophy in the rabbit

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12 December 2020

Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles

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12 December 2020

Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts

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12 December 2020

Power output is increased after phosphorylation of myofibrillar proteins in rat skinned cardiac myocytes

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12 December 2020

Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process

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12 December 2020

Altered oscillatory work by ventricular myofilaments from a rabbit coronary artery ligation model of heart failure

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12 December 2020

Force-frequency relation in patients with left ventricular hypertrophy and failure

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12 December 2020

Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocyte contractile dysfunction in heart failure

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12 December 2020

Altered myocardial force-frequency relation in human heart failure

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12 December 2020

Beta-protein kinase C and hypertrophic signaling in human heart failure

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12 December 2020

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

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12 December 2020

A mechanistic analysis of the force-frequency relation in non-failing and progressively failing human myocardium

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12 December 2020

Role of protein phosphatases in regulation of cardiac inotropy and relaxation

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12 December 2020

Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoforms

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12 December 2020

Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics.

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12 December 2020

Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation

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12 December 2020

Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species

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12 December 2020

Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1

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12 December 2020

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

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12 December 2020

Cardiac troponin T isoforms demonstrate similar effects on mechanical performance in a regulated contractile system

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12 December 2020

Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties

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12 December 2020

Molecular and integrated biology of thin filament protein phosphorylation in heart muscle

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12 December 2020

The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium

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12 December 2020

Troponin I phosphorylation in the normal and failing adult human heart

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12 December 2020

Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardium.

1 reference

12 December 2020

Decreased contractile efficiency and increased nonmechanical energy cost in hyperthyroid rabbit heart. Relation between O2 consumption and systolic pressure-volume area or force-time integral

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12 December 2020

Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure

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12 December 2020

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1 reference

12 December 2020

Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot

1 reference

12 December 2020

Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin

1 reference

12 December 2020

Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension

1 reference

12 December 2020

Ventricular energetics

1 reference

12 December 2020

Alterations of myocardial dynamic stiffness implicating abnormal crossbridge function in human mitral regurgitation heart failure

1 reference

12 December 2020

Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency

1 reference

12 December 2020

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function

1 reference

12 December 2020

Identification and validation of selective upregulation of ventricular myosin light chain type 2 mRNA in idiopathic dilated cardiomyopathy.

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12 December 2020

Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy

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12 December 2020

Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2

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12 December 2020

10.1007/S10741-005-5254-4

Identifiers

DOI

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13 August 2017

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PubMed ID

16416047