Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders (Q28248358)

Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages

Europe PubMed Central

title

Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders (English)

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Pooja M Bhatt

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Ramiro Malgor

series ordinal

2

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language of work or name

English

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publication date

November 2014

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published in

Atherosclerosis

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volume

237

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page(s)

155-62

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issue

1

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cites work

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Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

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Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2

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The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

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Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells

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A new secreted protein that binds to Wnt proteins and inhibits their activities

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Wnt family proteins are secreted and associated with the cell surface

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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

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The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification

20 March 2017

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Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes

20 March 2017

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Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions

29 September 2017

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The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

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Wnt5a activates THP-1 monocytic cells via a β-catenin-independent pathway involving JNK and NF-κB activation

29 September 2017

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Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients

29 September 2017

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Wnt5a: its signalling, functions and implication in diseases

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Different responses to oxidized low-density lipoproteins in human polarized macrophages

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Wnt5a induces endothelial inflammation via beta-catenin-independent signaling

29 September 2017

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29 September 2017

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High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration

29 September 2017

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Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

29 September 2017

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STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review).

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Wnts as ligands: processing, secretion and reception

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Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines

29 September 2017

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Macrophages in inflammation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Expression and function of wingless and frizzled homologs in rheumatoid arthritis.

29 September 2017

1 reference

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Atherosclerosis is an inflammatory disease

29 September 2017

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29 September 2017

1 reference

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siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways

29 September 2017

1 reference

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Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans

2 June 2018

1 reference

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A sandwich ELISA for the detection of Wnt5a

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

Increased expression of Wnt5a in psoriatic plaques.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252768

The novel role and underlying mechanism of Wnt5a in regulating cellular cholesterol accumulation

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25240110

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25240110