Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits (Q28219397)

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scientific article (publication date: August 2007)

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English	Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits	scientific article (publication date: August 2007)

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scholarly article

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Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits (English)

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based on heuristic

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author name string

Pancras C Wong

1

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Earl J Crain

2

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Carol A Watson

3

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Ruth R Wexler

4

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Patrick Y S Lam

5

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Mimi L Quan

6

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Robert M Knabb

7

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language of work or name

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publication date

August 2007

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Journal of Thrombosis and Thrombolysis

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24

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1

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43-51

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https://scigraph.springernature.com/pub.10.1007/s11239-007-0017-9

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Antithrombotic efficacy of a novel murine antihuman factor IX antibody in rats.

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https://api.crossref.org/works/10.1007%2FS11239-007-0017-9

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Nonpeptide factor Xa inhibitors: DPC423, a highly potent and orally bioavailable pyrazole antithrombotic agent.

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Oral antiplatelet efficacy and specificity of a novel nonpeptide platelet GPIIb/IIIa receptor antagonist, DMP 802.

1 reference

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Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis

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A comparative study of prothrombinase and thrombin inhibitors in a novel rabbit model of non-occlusive deep vein thrombosis

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Antiplatelet drugs and generation of thrombin in clotting blood

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BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study

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Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis

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Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

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Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor

1 reference

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A human antibody that inhibits factor IX/IXa function potently inhibits arterial thrombosis without increasing bleeding

1 reference

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Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25,307 patients

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Coagulation factor Xa inhibition: biological background and rationale

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The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study)

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Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat

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Combined antithrombotic therapy for acute coronary syndrome

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The design and synthesis of noncovalent factor Xa inhibitors

1 reference

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Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17323133

12 December 2020

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Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel

1 reference

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Prevention of cardiovascular events after acute coronary syndrome

1 reference

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inferred from PubMed ID database lookup

Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17323133

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11239-007-0017-9

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