C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4 (Q28202641)

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P Iakova

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M Wilde

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A Welm

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T Goode

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W J Roesler

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N A Timchenko

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

7

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language of work or name

English

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publication date

October 2001

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published in

Molecular Cell

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volume

8

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page(s)

817-28

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issue

4

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cites work

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Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs

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Identification of CDK4 sequences involved in cyclin D1 and p16 binding

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Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes

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The regulation of E2F by pRB-family proteins

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Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha

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CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding

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Inhibition of cyclin-dependent kinases by p21

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Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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Separation of C/EBPalpha-mediated proliferation arrest and differentiation pathways.

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Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator.

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CDK inhibitors: positive and negative regulators of G1-phase progression

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

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CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice

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C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

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E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes

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Impaired energy homeostasis in C/EBP alpha knockout mice

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Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins

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CCAAT-enhancer binding protein: a component of a differentiation switch

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Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation

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7 January 2021