Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter (Q28201214)

1

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Isabelle Manfroid

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Daniel Moncet

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Ginette Gunz

4

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Marc Muller

5

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Michel Grino

6

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Alain Enjalbert

7

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Isabelle Pellegrini

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

15 November 2002

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published in

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volume

277

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page(s)

44408-16

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issue

46

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cites work

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Far upstream sequences regulate the human prolactin promoter transcription

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

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Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter

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Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types

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Transcription factor AP1 is involved in basal and okadaic acid-stimulated activity of the human PRL promoter

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Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone-regulated activity

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Thyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements

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The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter

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Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription

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A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins

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NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene

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Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

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Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development.

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A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice

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