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scientific article (publication date: 10 August 2001)

Language	Label	Description	Also known as
English	No label defined	scientific article (publication date: 10 August 2001)

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scholarly article

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Real-time monitoring of the interactions of transforming growth factor-beta (TGF-beta ) isoforms with latency-associated protein and the ectodomains of the TGF-beta type II and III receptors reveals different kinetic models and stoichiometries of binding (English)

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author name string

G De Crescenzo

1

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S Grothe

2

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J Zwaagstra

3

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M Tsang

4

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M D O'Connor-McCourt

5

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language of work or name

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publication date

10 August 2001

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Journal of Biological Chemistry

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276

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29632-43

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32

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Inflammatory and immunomodulatory roles of TGF-beta.

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TGFbeta signaling in growth control, cancer, and heritable disorders

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TGF beta signals through a heteromeric protein kinase receptor complex

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TGF-beta signal transduction

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Betaglycan presents ligand to the TGF beta signaling receptor.

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Mapping of the ligand binding domain of the transforming growth factor beta receptor type III by deletion mutagenesis

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Betaglycan has multiple binding sites for transforming growth factor-beta 1.

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Ligand-dependent and -independent interactions with the transforming growth factor type II and I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunit

1 reference

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Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

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The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands

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Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane

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Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII).

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BIAcore for macromolecular interaction

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Analysis of small latent transforming growth factor-beta complex formation and dissociation by surface plasmon resonance. Absence of direct interaction with thrombospondins.

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Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide

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Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily

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The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding

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Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2

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Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells

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Ligand-induced dimerization of the extracellular domain of the TGF-beta receptor type II.

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Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist

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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling

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Crystal structure of the BMP-2-BRIA ectodomain complex

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Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

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Down-regulation of transforming growth factor-beta receptors: cooperativity between the types I, II, and III receptors and modulation at the cell surface

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Model and Simulation of Multivalent Binding to Fixed Ligands

1 reference

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The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor

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21 January 2018

Mutagenesis analysis of the membrane-proximal ligand binding site of the TGF-beta receptor type III extracellular domain

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An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct

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Surface plasmon resonance based methods for measuring the kinetics and binding affinities of biomolecular interactions

1 reference

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Analysis of the interaction between two TGF-beta-binding proteins and three TGF-beta isoforms using surface plasmon resonance

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Ectodomain cleavage and shedding of the type III transforming growth factor-beta receptor in lung membranes effect of temperature, ligand binding and membrane solubilization

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21 January 2018

Identifiers

10.1074/JBC.M009765200

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