The emerging role of lysophosphatidic acid in cancer (Q28191543)

Europe PubMed Central

title

The emerging role of lysophosphatidic acid in cancer (English)

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1

Gordon B Mills

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author name string

Wouter H Moolenaar

series ordinal

2

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language of work or name

English

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publication date

August 2003

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published in

Nature Reviews Cancer

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volume

3

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page(s)

582-91

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issue

8

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cites work

The Hallmarks of Cancer

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Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

31 March 2020

1 reference

Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D.

31 March 2020

1 reference

Lysophospholipids activate ovarian and breast cancer cells

31 March 2020

1 reference

Effect of lysophospholipids on signaling in the human Jurkat T cell line

31 March 2020

1 reference

Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein

31 March 2020

1 reference

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

31 March 2020

1 reference

Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid

31 March 2020

1 reference

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

31 March 2020

1 reference

Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade.

31 March 2020

1 reference

Lysophosphatidic acid-induced neurite retraction in PC12 cells: control by phosphoinositide-Ca2+ signaling and Rho

31 March 2020

1 reference

Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells.

31 March 2020

1 reference

Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src

31 March 2020

1 reference

Lysophospholipids increase interleukin-8 expression in ovarian cancer cells

31 March 2020

1 reference

Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane

31 March 2020

1 reference

Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells

31 March 2020

1 reference

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

31 March 2020

1 reference

Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells

31 March 2020

1 reference

Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid.

31 March 2020

1 reference

Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing

31 March 2020

1 reference

Phospholipid growth factors and corneal wound healing

31 March 2020

1 reference

Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo

31 March 2020

1 reference

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

31 March 2020

1 reference

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

31 March 2020

1 reference

Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells

31 March 2020

1 reference

Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury

31 March 2020

1 reference

Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta

31 March 2020

1 reference

Lysophosphatidic acid enhances contractility of isolated airway smooth muscle

31 March 2020

1 reference

A novel lysophosphatidic acid analog, LXR-1035, inhibits leukocyte-endothelium interaction via inhibition of cell adhesion molecules

31 March 2020

1 reference

Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids

31 March 2020

1 reference

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

31 March 2020

1 reference

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

31 March 2020

1 reference

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist

31 March 2020

1 reference

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

31 March 2020

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Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways

31 March 2020

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Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction

31 March 2020

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Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.

31 March 2020

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Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

31 March 2020

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Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

31 March 2020

1 reference

Rho GTPases in cell biology

31 March 2020

1 reference

PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor

31 March 2020

1 reference

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

31 March 2020

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Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex

31 March 2020

1 reference

Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid

31 March 2020

1 reference

Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid

31 March 2020

1 reference

Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid

31 March 2020

1 reference

Lysophospholipids--receptor revelations

31 March 2020

1 reference

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

31 March 2020

1 reference

The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern

31 March 2020

1 reference

Lysophosphatidic acid is a bioactive mediator in ovarian cancer

31 March 2020

1 reference

Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer

31 March 2020

1 reference

Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior

31 March 2020

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Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2).

31 March 2020

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Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes.

31 March 2020

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Analysis of the EDG2 receptor based on the structure/activity relationship of LPA.

31 March 2020

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A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors

31 March 2020

1 reference

Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist.

31 March 2020

1 reference

Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.

31 March 2020

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Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor

31 March 2020

1 reference

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

31 March 2020

1 reference

Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors.

31 March 2020

1 reference

Gelsolin binding and cellular presentation of lysophosphatidic acid

31 March 2020

1 reference

The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

31 March 2020

1 reference

Serum lysophosphatidic acid is produced through diverse phospholipase pathways

31 March 2020

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Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood.

31 March 2020

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A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells

31 March 2020

1 reference

Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

31 March 2020

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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

31 March 2020

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Roles for lipid phosphate phosphatases in regulation of cellular signaling

31 March 2020

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Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers

31 March 2020

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Plasma lysophosphatidic acid concentration and ovarian cancer

31 March 2020

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Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors

31 March 2020

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Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

31 March 2020

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Malignant effusions and immunogenic tumour-derived exosomes

31 March 2020

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The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site

31 March 2020

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Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling

31 March 2020

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Characterization of plasma unsaturated lysophosphatidylcholines in human and rat

31 March 2020

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Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

31 March 2020

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Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells

31 March 2020

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Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells

31 March 2020

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Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells

31 March 2020

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Malignant effusions contain lysophosphatidic acid (LPA)-like activity

31 March 2020

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Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: comparison of the lysophospholipid contents in malignant vs nonmalignant ascitic fluids

31 March 2020

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Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not from breast or leukemia cells

31 March 2020

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The significance of plasma lysophospholipids in patients with renal failure on hemodialysis

31 March 2020

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Abnormal serum lysophospholipids in multiple myeloma patients

31 March 2020

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Elevated levels and altered fatty acid composition of plasma lysophosphatidylcholine(lysoPC) in ovarian cancer patients.

31 March 2020

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Quantitative analysis of acyl-lysophosphatidic acid in plasma using negative ionization tandem mass spectrometry

31 March 2020

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Fatty acid composition of lysophosphatidic acid and lysophosphatidylinositol in plasma from patients with ovarian cancer and other gynecological diseases

31 March 2020

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Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors

31 March 2020

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Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis

31 March 2020

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Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors

1 reference