Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway (Q28187612)

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P Nollau

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H Y Ho

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M W Kirschner

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B J Mayer

Journal of Biological Chemistry

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language of work or name

English

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publication date

13 July 2001

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published in

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volume

276

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issue

28

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page(s)

26448-52

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cites work

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Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

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The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

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Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

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Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

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Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

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Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors

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Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

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A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

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Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.

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Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

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Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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