Structure and regulation of mammalian squalene synthase (Q28139740)

Biochimica et Biophysica Acta

Europe PubMed Central

title

Structure and regulation of mammalian squalene synthase (English)

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T R Tansey

1

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I Shechter

series ordinal

2

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language of work or name

English

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publication date

15 December 2000

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published in

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volume

1529

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page(s)

49-62

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issue

1-3

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cites work

The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Biosynthesis of non-head-to-tail terpenes. Formation of 1'-1 and 1'-3 linkages

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Squalene synthase: Structure and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Purification to homogeneity and some properties of squalene synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Squalene synthase inhibitors: their potential as hypocholesterolaemic agents.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Carotenoids 2: Genetics and molecular biology of carotenoid pigment biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Carotenoid biosynthesis: Isolation and characterization of a bifunctional enzyme catalyzing the synthesis of phytoene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Molecular cloning and characterization of the yeast gene for squalene synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Chain elongation in the isoprenoid biosynthetic pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Creating isoprenoid diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Regulation of product chain length by isoprenyl diphosphate synthases

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Squalene synthetase activity in human fibroblasts: Regulation via the low density lipoprotein receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Effects of endotoxin and cytokines on lipid metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Molecular cloning and functional analysis of the promoter of the human squalene synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

ADD-1 provides major new insight into the mechanism of insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

The physiological role of sterol regulatory element-binding protein-2 in cultured human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Molecular cloning and functional expression of a cDNA for mouse squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2800%2900137-2

7 January 2021

10.1016/S1388-1981(00)00137-2

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4850160

OpenCitations bibliographic resource ID

4850160

1 reference