Squalene synthase: Structure and regulation (Q60060706)

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

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7 January 2021

Cholesterol modification of hedgehog signaling proteins in animal development

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cholesterol metabolism and embryogenesis

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Physical-Chemical Basis of Lipid Deposition in Atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Teratogen-mediated inhibition of target tissue response to Shh signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Regulation of the mevalonate pathway

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Biosynthesis of non-head-to-tail terpenes. Formation of 1'-1 and 1'-3 linkages

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Polyisoprenyl phosphates in intracellular signalling.

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Orphan nuclear receptors: shifting endocrinology into reverse

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Stereoselective total synthesis of (+-)-presqualene alcohol

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Synthesis and conversion of presqualene alcohol to squalene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Mechanism of presqualene pyrophosphate-squalene biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Purification to homogeneity and some properties of squalene synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Physiological implications of sterol biosynthesis in yeast

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Regulation of squalene synthetase and squalene epoxidase activities in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase

1 reference

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7 January 2021

Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Truncation of human squalene synthase yields active, crystallizable protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase

1 reference

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7 January 2021

Cell compartmentalization of cholesterol biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Subcellular localization of squalene synthase in human hepatoma cell line Hep G2

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

1 reference

7 January 2021

The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Chain elongation in the isoprenoid biosynthetic pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Creating isoprenoid diversity

1 reference

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7 January 2021

Carotenoids 2: Genetics and molecular biology of carotenoid pigment biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Enzymatic synthesis of phytoene.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Multiple determinants direct the orientation of signal-anchor proteins: the topogenic role of the hydrophobic signal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Signal sequences: more than just greasy peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Structure and function of a squalene cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

The Cationminus signpi Interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Molecular cloning and functional expression of a cDNA for mouse squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Identification and regulation of rat squalene synthetase mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Studies on the site of the feedback control of cholesterol synthesis

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Proceedings of the Biochemical Society

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Molecular cloning and functional analysis of the promoter of the human squalene synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

The physiological role of sterol regulatory element-binding protein-2 in cultured human cells

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Effects of endotoxin and cytokines on lipid metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Effect of interleukin-1 alpha on lipoprotein lipids in cynomolgus monkeys: comparison to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Transforming growth factor-beta 1 and interleukin-1 beta stimulate LDL receptor activity in Hep G2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

A uniform alteration in serum lipid metabolism occurring during inflammation in mice

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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Squalene synthase inhibitors: their potential as hypocholesterolaemic agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021

Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5

7 January 2021