CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling (Q28117541)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling (English)

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

CYLD lysine 63 deubiquitinase

12 March 2020

main subject

1 reference

OTU deubiquitinase with linear linkage specificity

GOA release 2020-03-11

1 reference

protein linear deubiquitination

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Matouš Hrdinka

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Rune Busk Damgaard

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

9

David Komander

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Berthe Katrine Fiil

2

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Mattia Zucca

3

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Derek Leske

4

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Katrin Bagola

5

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Monica Yabal

6

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Mads Gyrd-Hansen

11

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Paul R Elliott

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Philipp J Jost

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

publication date

17 March 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

14

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

12

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

2846-2858

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

12 March 2020

cites work

1 reference

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

20 March 2017

1 reference

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OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Critical role for Daxx in regulating Mdm2

20 March 2017

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Linear ubiquitination prevents inflammation and regulates immune signalling

20 March 2017

1 reference

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

20 March 2017

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

20 March 2017

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

20 March 2017

1 reference

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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

20 March 2017

1 reference

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A ubiquitin ligase complex assembles linear polyubiquitin chains

20 March 2017

1 reference

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ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

20 March 2017

1 reference

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

20 March 2017

1 reference

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

20 March 2017

1 reference

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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

The role of ubiquitylation in immune defence and pathogen evasion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

XIAP regulates cytosol-specific innate immunity to Listeria infection

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819907

Identification of the familial cylindromatosis tumour-suppressor gene

20 March 2017

1 reference

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NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

20 March 2017

1 reference

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Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

20 March 2017

1 reference

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The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

20 March 2017

1 reference

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LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

20 March 2017

1 reference

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Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

29 September 2017

1 reference

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Assembly and specific recognition of k29- and k33-linked polyubiquitin.

29 September 2017

1 reference

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Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).

29 September 2017

1 reference

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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

29 September 2017

1 reference

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Met1-linked ubiquitination in immune signalling

29 September 2017

1 reference

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NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

29 September 2017

1 reference

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NOD proteins: regulators of inflammation in health and disease

29 September 2017

1 reference

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

29 September 2017

1 reference

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CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production

29 September 2017

1 reference

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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

29 September 2017

1 reference

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Regulation of NF-κB by deubiquitinases

29 September 2017

1 reference

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Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

29 September 2017

1 reference

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

29 September 2017

1 reference

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

29 September 2017

1 reference

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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

29 September 2017

1 reference

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A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.

2 June 2018

1 reference

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Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells

2 June 2018

1 reference

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Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

2 June 2018

1 reference

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Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.

27 November 2018

1 reference

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

27 November 2018

1 reference

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Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26997266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2016.02.062

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26997266%20AND%20SRC:MED&resulttype=core&format=json