BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain (Q28116760)

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29 January 2020

title

BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain (English)

2 references

4 January 2017

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29 January 2020

main subject

phosphorylation

0 references

Bromodomain containing 4

1 reference

RNA polymerase II C-terminal domain binding

1 reference

Bromodomain containing 4

1 reference

Cyclin-dependent kinase 9 (CDC2-related kinase)

1 reference

Polymerase (RNA) II (DNA directed) polypeptide A

1 reference

author

Pamela Robey

6

1 reference

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29 January 2020

author name string

Natasha Cherman

3

2 references

4 January 2017

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29 January 2020

Keiko Ozato

7

2 references

4 January 2017

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29 January 2020

Ballachanda N Devaiah

1

1 reference

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29 January 2020

Brian A Lewis

2

1 reference

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29 January 2020

Michael C Hewitt

4

1 reference

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29 January 2020

Brian K Albrecht

5

1 reference

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29 January 2020

Robert J Sims

8

1 reference

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29 January 2020

Dinah S Singer

9

1 reference

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29 January 2020

language of work or name

English

0 references

publication date

16 April 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

29 January 2020

published in

2 references

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volume

109

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29 January 2020

page(s)

6927-6932

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29 January 2020

issue

18

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4 January 2017

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A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

29 January 2020

cites work

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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

20 March 2017

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

20 March 2017

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A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

20 March 2017

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Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

20 March 2017

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20 March 2017

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

20 March 2017

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BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

20 March 2017

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

20 March 2017

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The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

20 March 2017

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Controlling the elongation phase of transcription with P-TEFb

20 March 2017

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Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

20 March 2017

1 reference

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A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator

20 March 2017

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Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

20 March 2017

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Progression through the RNA polymerase II CTD cycle

20 March 2017

1 reference

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Phosphorylation and functions of the RNA polymerase II CTD

7 April 2017

1 reference

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

7 April 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

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Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer.

7 April 2017

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The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

29 September 2017

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29 September 2017

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Bromodomain 4 activation predicts breast cancer survival

29 September 2017

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Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7.

29 September 2017

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The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression

29 September 2017

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C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats

29 September 2017

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29 September 2017

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In-gel kinase assay as a method to identify kinase substrates

29 September 2017

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Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

29 September 2017

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

29 September 2017

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Cell cycle regulation and RNA polymerase II.

29 September 2017

1 reference

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Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene

29 September 2017

1 reference

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Adult stem cells exhibit global suppression of RNA polymerase II serine-2 phosphorylation

29 September 2017

1 reference

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Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1120422109

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

21 January 2018

1 reference

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27 November 2018

Identifiers

DOI

10.1073/PNAS.1120422109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509028%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

ADS bibcode

2012PNAS..109.6927D

0 references

1 reference

2 references

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29 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509028%20AND%20SRC:MED&resulttype=core&format=json