Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts (Q28116245)

4 January 2017

title

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts (English)

1 reference

Leucine rich repeat kinase 2

4 January 2017

main subject

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

Leucine-rich repeat kinase 2

GOA release 2020-03-11

1 reference

Christian Johannes Gloeckner

GOA release 2020-03-11

2 references

19

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22

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Karsten Boldt

10

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Michael Sattler

Pravin Kumar Ankush Jagtap

17

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object named as

Pravin Kumar Ankush Jagtap

9

0 references

Wim Versées

object named as

Wim Versées

18

0 references

Alex B. Burgin

15

object named as

Alex Burgin

1 reference

4 January 2017

11

Felix von Zweydorf

1 reference

4 January 2017

14

Zhenyu Yue

1 reference

4 January 2017

author name string

Giambattista Guaitoli

1

1 reference

4 January 2017

Francesco Raimondi

2

1 reference

4 January 2017

Bernd K. Gilsbach

3

1 reference

4 January 2017

Yacob Gómez-Llorente

4

1 reference

4 January 2017

Egon Deyaert

5

1 reference

4 January 2017

Fabiana Renzi

6

1 reference

4 January 2017

Xianting Li

7

1 reference

4 January 2017

Adam Schaffner

8

1 reference

4 January 2017

Katja Gotthardt

12

1 reference

4 January 2017

Donald D. Lorimer

13

1 reference

4 January 2017

Nebojsa Janjic

16

1 reference

4 January 2017

Iban Ubarretxena-Belandia

20

1 reference

4 January 2017

Arjan Kortholt

21

1 reference

4 January 2017

language of work or name

English

0 references

publication date

26 July 2016

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 January 2017

published in

1 reference

4 January 2017

volume

113

1 reference

4 January 2017

issue

30

1 reference

4 January 2017

page(s)

E4357–4366

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

4 January 2017

cites work

1 reference

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

20 March 2017

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Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

20 March 2017

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

20 March 2017

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GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

20 March 2017

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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

20 March 2017

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

20 March 2017

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

20 March 2017

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Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

20 March 2017

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Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

20 March 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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22 April 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

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7 April 2017

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7 April 2017

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The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.

22 April 2017

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Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

29 September 2017

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29 September 2017

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Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

29 September 2017

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Contribution of GTPase activity to LRRK2-associated Parkinson disease

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The GTPase function of LRRK2.

29 September 2017

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29 September 2017

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

29 September 2017

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Molecular pathogenesis of Parkinson disease: insights from genetic studies

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.

2 June 2018

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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

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PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

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DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering

21 January 2018

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Automated matching of high- and low-resolution structural models

21 January 2018

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Protein-protein docking with backbone flexibility.

21 January 2018

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Xmipp: An Image Processing Package for Electron Microscopy

21 January 2018

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Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

21 January 2018

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27 November 2018

Identifiers

DOI

10.1073/PNAS.1523708113

0 references

PMC publication ID

4968714

0 references

1 reference