Determinants of cation transport selectivity: Equilibrium binding and transport kinetics (Q28080724)

main subject

physiological phenomenon

1 reference

20 August 2019

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4 November 2019

2 references

22 July 2020

31 January 2021

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4 November 2020

Steve W. Lockless

1

1 reference

language of work or name

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July 2015

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The Journal of General Physiology

1 July 2015

5 references

20 August 2019

4 November 2019

22 July 2020

4 November 2020

31 January 2021

6 references

20 August 2019

4 November 2019

22 July 2020

4 November 2020

31 January 2021

146

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page(s)

3-13

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issue

1

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Ionic interactions of Ba 2+ blockades in the MthK K + channel

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Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels

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Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state

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The structure of the KtrAB potassium transporter

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Gating of the TrkH ion channel by its associated RCK protein TrkA

20 March 2017

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Binding thermodynamics of a glutamate transporter homolog

20 March 2017

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Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes

20 March 2017

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Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger

20 March 2017

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Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel

20 March 2017

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Crystal structure of the human two-pore domain potassium channel K2P1

20 March 2017

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Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

20 March 2017

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Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation

20 March 2017

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Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

20 March 2017

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Crystal structure of a potassium ion transporter, TrkH

20 March 2017

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Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore

20 March 2017

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Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

20 March 2017

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Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore

20 March 2017

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Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

20 March 2017

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Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

20 March 2017

1 reference

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Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA pore

20 March 2017

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Structure and mechanism of an amino acid antiporter

20 March 2017

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Crystal structure of full-length KcsA in its closed conformation

20 March 2017

1 reference

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Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP

20 March 2017

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High-resolution structure of the open NaK channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Structural analysis of ion selectivity in the NaK channel

20 March 2017

1 reference

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Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

20 March 2017

1 reference

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

20 March 2017

1 reference

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Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

20 March 2017

1 reference

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Tuning ion coordination architectures to enable selective partitioning

20 March 2017

1 reference

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Structural and thermodynamic properties of selective ion binding in a K+ channel

20 March 2017

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Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

20 March 2017

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Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels

20 March 2017

1 reference

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The Occupancy of Ions in the K+ Selectivity Filter: Charge Balance and Coupling of Ion Binding to a Protein Conformational Change Underlie High Conduction Rates

20 March 2017

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Crystal structure of the potassium channel KirBac1.1 in the closed state

20 March 2017

1 reference

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X-ray structure of a voltage-dependent K+ channel

20 March 2017

1 reference

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Crystal structure and mechanism of a calcium-gated potassium channel

20 March 2017

1 reference

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X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

20 March 2017

1 reference

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Energetic optimization of ion conduction rate by the K+ selectivity filter

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

TrkH and its homolog, TrkG, determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Negative Conductance Caused by Entry of Sodium and Cesium Ions into the Potassium Channels of Squid Axons

20 March 2017

1 reference

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Atomic structure of a Na+- and K+-conducting channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2K

7 April 2017

1 reference

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Permeation redux: thermodynamics and kinetics of ion movement through potassium channels

29 September 2017

1 reference

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Sodium and potassium competition in potassium-selective and non-selective channels.

29 September 2017

1 reference

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Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains

29 September 2017

1 reference

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On the selective ion binding hypothesis for potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Structural correlates of selectivity and inactivation in potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Potassium-selective block of barium permeation through single KcsA channels

29 September 2017

1 reference

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Perspectives on: ion selectivity: design principles for K+ selectivity in membrane transport.

29 September 2017

1 reference

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A multipoint hydrogen-bond network underlying KcsA C-type inactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Thermodynamics of ion selectivity in the KcsA K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Ion selectivity in channels and transporters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Origins of ion selectivity in potassium channels from the perspective of channel block.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Structural studies of ion selectivity in tetrameric cation channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension

29 September 2017

1 reference

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Ion selectivity of the KcsA channel: a perspective from multi-ion free energy landscapes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Conformational dynamics in the selectivity filter of KcsA in response to potassium ion concentration

29 September 2017

1 reference

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Enhancement of transport selectivity through nano-channels by non-specific competition

29 September 2017

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Structural basis underlying the dual gate properties of KcsA

29 September 2017

1 reference

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Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Effects of multiple occupancy and interparticle interactions on selective transport through narrow channels: theory versus experiment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

K+/Na+ selectivity in K channels and valinomycin: over-coordination versus cavity-size constraints

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Ion selectivity in potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Molecular determinants of gating at the potassium-channel selectivity filter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

CNG and HCN channels: two peas, one pod.

29 September 2017

1 reference

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Principles of selective ion transport in channels and pumps

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

K(+)/Na(+) selectivity of the KcsA potassium channel from microscopic free energy perturbation calculations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Ion conduction through C-type inactivated Shaker channels.

29 September 2017

1 reference

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Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Conduction properties of the cloned Shaker K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Mutations in the K+ channel signature sequence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Potassium flux ratio in voltage-clamped squid giant axons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Genetic analysis of potassium transport loci in Escherichia coli: evidence for three constitutive systems mediating uptake potassium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Potassium channels as multi-ion single-file pores

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Permeation selectivity by competition in a delayed rectifier potassium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Unidirectional flux ratio for potassium ions in depolarized frog skeletal muscle.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Mechanism of ion permeation through calcium channels

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Structure of the K+ complex with nonactin, a macrotetrolide antibiotic possessing highly specific K+ transport properties

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + Channels

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

The crystal structure of a K+ complex of valinomycin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485025

Equilibrium selectivity alone does not create K+-selective ion conduction in K+ channels.

2 June 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Preferential binding of K+ ions in the selectivity filter at equilibrium explains high selectivity of K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Ion binding properties and structure stability of the NaK channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Single-file diffusion through the Ca2+-activated K+ channel of human red cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Ion binding affinity in the cavity of the KcsA potassium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201511371

Molecular strategies to achieve selective conductance in NaK channel variants

21 January 2018

1 reference

12 December 2020

Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium

1 reference

12 December 2020

The potassium permeability of a giant nerve fibre

1 reference

12 December 2020

Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin

1 reference

12 December 2020

The crystal structure of the NaNCS complex of nonactin

1 reference

12 December 2020