Overcoming mutation-based resistance to antiandrogens with rational drug design (Q28044590)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23580326%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Overcoming mutation-based resistance to antiandrogens with rational drug design (English)

1 reference

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28 February 2020

9

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8

Geoffrey L Greene

1 reference

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28 February 2020

5

Vivek K Arora

1 reference

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28 February 2020

author name string

Minna D Balbas

1

1 reference

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28 February 2020

Michael J Evans

2

1 reference

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28 February 2020

David J Hosfield

3

1 reference

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28 February 2020

John Wongvipat

4

1 reference

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28 February 2020

Philip A Watson

6

1 reference

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28 February 2020

Yu Chen

7

1 reference

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28 February 2020

Charles L Sawyers

10

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28 February 2020

language of work or name

English

0 references

publication date

9 April 2013

1 reference

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28 February 2020

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28 February 2020

volume

2

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28 February 2020

page(s)

e00499

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describes a project that uses

28 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3622181/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)

20 March 2017

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The Sequence Alignment/Map format and SAMtools

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Fast and accurate short read alignment with Burrows-Wheeler transform

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Development of a second-generation antiandrogen for treatment of advanced prostate cancer

20 March 2017

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Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

20 March 2017

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Structural basis for antagonism and resistance of bicalutamide in prostate cancer

20 March 2017

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Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

20 March 2017

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

20 March 2017

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Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing

20 March 2017

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Molecular determinants of resistance to antiandrogen therapy

20 March 2017

1 reference

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The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay

20 March 2017

1 reference

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Increased survival with enzalutamide in prostate cancer after chemotherapy

20 March 2017

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Overriding imatinib resistance with a novel ABL kinase inhibitor

7 April 2017

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Converting cancer therapies into cures: lessons from infectious diseases

22 April 2017

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ARN-509: a novel antiandrogen for prostate cancer treatment

29 September 2017

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

29 September 2017

1 reference

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Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor.

29 September 2017

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Pleiotropic functional properties of androgen receptor mutants in prostate cancer.

29 September 2017

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Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients

29 September 2017

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Use of the PSA enhancer core element to modulate the expression of prostate- and non-prostate-specific basal promoters in a lentiviral vector context

29 September 2017

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29 September 2017

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Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

29 September 2017

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29 September 2017

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29 September 2017

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Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer

29 September 2017

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A single amino acid that determines the sensitivity of progesterone receptors to RU486.

29 September 2017

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A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

29 September 2017

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

2 June 2018

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CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

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21 January 2018

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Androgen receptor alterations in prostate cancer relapsed during a combined androgen blockade by orchiectomy and bicalutamide

21 January 2018

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Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer.

21 January 2018

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21 January 2018

Identifiers

DOI

10.7554/ELIFE.00499

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23580326%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23580326%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

2 references