PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. (Q27935500)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

DNA repair protein SMC6 YLR383W

1 reference

SUMO ligase MMS21 YEL019C

1 reference

SUMO ligase SIZ1 YDR409W

1 reference

SUMO ligase NFI1 YOR156C

1 reference

author

Susan M. Gasser

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

author name string

Chihiro Horigome

1

1 reference

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31 March 2020

Denise E Bustard

2

1 reference

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31 March 2020

Isabella Marcomini

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Neda Delgoshaie

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Monika Tsai-Pflugfelder

5

1 reference

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31 March 2020

Jennifer A Cobb

6

1 reference

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31 March 2020

language of work or name

English

0 references

publication date

7 April 2016

1 reference

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31 March 2020

2 references

1 December 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

volume

30

1 reference

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31 March 2020

issue

8

1 reference

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31 March 2020

page(s)

931-945

1 reference

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describes a project that uses

31 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4840299/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements

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Effect of nuclear architecture on the efficiency of double-strand break repair

20 March 2017

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Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair

20 March 2017

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The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.

20 March 2017

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

20 March 2017

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The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation

20 March 2017

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20 March 2017

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The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

20 March 2017

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Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes

20 March 2017

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Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

20 March 2017

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Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence

20 March 2017

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Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region

20 March 2017

1 reference

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SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.

20 March 2017

1 reference

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

20 March 2017

1 reference

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Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast

20 March 2017

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20 March 2017

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Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

20 March 2017

1 reference

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SUMO-mediated regulation of DNA damage repair and responses

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.

7 April 2017

1 reference

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Repair Pathway Choices and Consequences at the Double-Strand Break

29 September 2017

1 reference

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Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex

29 September 2017

1 reference

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DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA.

29 September 2017

1 reference

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Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

ATPase-dependent control of the Mms21 SUMO ligase during DNA repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Nuclear position dictates DNA repair pathway choice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The maintenance of chromosome structure: positioning and functioning of SMC complexes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

29 September 2017

1 reference

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Break-induced replication occurs by conservative DNA synthesis

29 September 2017

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Nuclear pore complexes in the maintenance of genome integrity.

29 September 2017

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Chromatin movement in the maintenance of genome stability.

29 September 2017

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The chromatin response to DNA breaks: leaving a mark on genome integrity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination

29 September 2017

1 reference

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Roles for nuclear organization in the maintenance of genome stability

29 September 2017

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Retracted: Rtt107 Phosphorylation Promotes Localisation to DNA Double-Stranded Breaks (DSBs) and Recombinational Repair between Sister Chromatids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

SUMO-targeted ubiquitin ligases in genome stability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Pds5 prevents the PolySUMO-dependent separation of sister chromatids.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

Genes required for ionizing radiation resistance in yeast

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4840299

DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27056668

12 December 2020

inferred from PubMed ID database lookup

Visualizing yeast chromosomes and nuclear architecture

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27056668

12 December 2020

inferred from PubMed ID database lookup

Visualizing the spatiotemporal dynamics of DNA damage in budding yeast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27056668

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1101/GAD.277665.116

2 references

Consolidated OpenCitations Corpus – April 2017

1426965

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1426965

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27056668%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

2 references

Consolidated OpenCitations Corpus – April 2017

1426965