FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. (Q27931304)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

title

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

Phosphatidylinositol kinase-related protein kinase TOR2 YKL203C

20 October 2019

main subject

1 reference

GOA release 2020-03-11

author name string

M E Cardenas

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

J Heitman

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

language of work or name

English

0 references

publication date

1 December 1995

1 reference

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20 October 2019

2 references

1 December 2016

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20 October 2019

volume

14

1 reference

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20 October 2019

page(s)

5892-5907

1 reference

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20 October 2019

issue

23

1 reference

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Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

20 October 2019

cites work

1 reference

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A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae.

20 March 2017

1 reference

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Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability

20 March 2017

1 reference

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PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.

20 March 2017

1 reference

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

20 March 2017

1 reference

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Cloning and characterization of a human phosphatidylinositol 4-kinase

20 March 2017

1 reference

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Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains

20 March 2017

1 reference

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20 March 2017

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20 March 2017

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The gene encoding the phosphatidylinositol transfer protein is essential for cell growth.

20 March 2017

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An essential role for a phospholipid transfer protein in yeast Golgi function

20 March 2017

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20 March 2017

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Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle

20 March 2017

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Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

20 March 2017

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

20 March 2017

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FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae

20 March 2017

1 reference

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Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase

20 March 2017

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Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants

20 March 2017

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New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

20 March 2017

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Fluorescence microscopy methods for yeast

20 March 2017

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

20 March 2017

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Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

20 March 2017

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Inositol trisphosphate and calcium signalling

20 March 2017

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

20 March 2017

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

20 March 2017

1 reference

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

20 March 2017

1 reference

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

20 March 2017

1 reference

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Recent insights in phosphatidylinositol signaling

20 March 2017

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

20 March 2017

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

20 March 2017

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

20 March 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

7 April 2017

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7 April 2017

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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

9 May 2017

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A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole

29 September 2017

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Phosphatidylinositol 3-kinase

29 September 2017

1 reference

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An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae

29 September 2017

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Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly

29 September 2017

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The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases

29 September 2017

1 reference

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Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions

29 September 2017

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FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

29 September 2017

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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.

29 September 2017

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Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands

29 September 2017

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29 September 2017

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29 September 2017

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Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast

29 September 2017

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A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterol

29 September 2017

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

29 September 2017

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

29 September 2017

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The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

29 September 2017

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Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate

29 September 2017

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The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B.

29 September 2017

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Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression

29 September 2017

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In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae

29 September 2017

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Changes in phospholipids of Saccharomyces cerevisiae associated with inositol-less death

29 September 2017

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Protein regulation by phosphatidylinositol lipids

29 September 2017

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FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

2 June 2018

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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

2 June 2018

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Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.

2 June 2018

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Intervacuole exchange in the yeast zygote: a new pathway in organelle communication

2 June 2018

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Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.

2 June 2018

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Methods for studying the yeast vacuole

2 June 2018

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The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

2 June 2018

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Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

2 June 2018

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

2 June 2018

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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

2 June 2018

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Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation.

2 June 2018

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ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

27 November 2018

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Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor.

27 November 2018

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Photoaffinity labeling of the 45-kDa and 55-kDa forms of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae

27 November 2018

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12 December 2020

Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis

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12 December 2020

Stimulation of cell proliferation and polyphosphoinositide metabolism in Saccharomyces cerevisiae GL7 by ergosterol

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12 December 2020

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

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12 December 2020

Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation

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12 December 2020

Activation of a low specific activity form of DNA polymerase alpha by inositol-1,4-bisphosphate

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12 December 2020

The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C

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12 December 2020

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

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12 December 2020

CDC25-dependent induction of inositol 1,4,5-trisphosphate and diacylglycerol in Saccharomyces cerevisiae by nitrogen

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12 December 2020

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast

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12 December 2020

10.1002/J.1460-2075.1995.TB00277.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8846782%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

2 references

1 December 2016