Epac: a new cAMP target and new avenues in cAMP research (Q43859972)

27 November 2017

Epac: a new cAMP target and new avenues in cAMP research (English)

1 reference

https://api.crossref.org/works/10.1038/NRM1197

27 November 2017

1 reference

13 March 2024

author name string

Johannes L. Bos

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14506476

13 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14506476

13 March 2024

publication date

1 September 2003

1 reference

full work available at URL

27 November 2017

http://www.nature.com/articles/nrm1197.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/NRM1197

http://www.nature.com/articles/nrm1197

13 March 2024

1 reference

https://api.crossref.org/works/10.1038/NRM1197

Nature Reviews Molecular Cell Biology

13 March 2024

published in

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27 November 2017

4

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27 November 2017

733-738

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27 November 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm1197

27 November 2017

0 references

cites work

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

31 March 2020

1 reference

A family of cAMP-binding proteins that directly activate Rap1

31 March 2020

1 reference

Structure and regulation of the cAMP-binding domains of Epac2

31 March 2020

1 reference

The structural basis of the activation of Ras by Sos

31 March 2020

1 reference

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

31 March 2020

1 reference

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

31 March 2020

1 reference

Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit

31 March 2020

1 reference

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

31 March 2020

1 reference

31 March 2020

1 reference

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

31 March 2020

1 reference

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

31 March 2020

1 reference

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

31 March 2020

1 reference

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

31 March 2020

1 reference

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

31 March 2020

1 reference

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

31 March 2020

1 reference

cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner

31 March 2020

1 reference

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

31 March 2020

1 reference

New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.

31 March 2020

1 reference

Rap1 signalling: adhering to new models

31 March 2020

1 reference

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

31 March 2020

1 reference

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

31 March 2020

1 reference

The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

31 March 2020

1 reference

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

31 March 2020

1 reference

The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration.

31 March 2020

1 reference

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

31 March 2020

1 reference

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

31 March 2020

1 reference

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

31 March 2020

1 reference

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

31 March 2020

1 reference

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

31 March 2020

1 reference

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

31 March 2020

1 reference

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b

31 March 2020

1 reference

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

31 March 2020

1 reference

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

31 March 2020

1 reference

Cyclic nucleotide research -- still expanding after half a century

31 March 2020

1 reference

The role of Rap1 in integrin-mediated cell adhesion

31 March 2020

1 reference

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

31 March 2020

1 reference

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

31 March 2020

1 reference

Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1197

1 reference

Dimensions Publication ID

27 November 2017

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