Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor (Q27735940)

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English	Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor	scientific article

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2 November 2019

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor (English)

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2 November 2019

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2 November 2019

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2 November 2019

David Ian Stuart

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2 November 2019

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R M Esnouf

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2 November 2019

A L Hopkins

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2 November 2019

C K Ross

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2 November 2019

D K Stammers

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1 April 1997

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2 November 2019

Proceedings of the National Academy of Sciences of the United States of America

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2 November 2019

94

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2 November 2019

3984-3989

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2 November 2019

8

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2 November 2019

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

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20 March 2017

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors

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The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

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20 March 2017

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

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20 March 2017

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution

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20 March 2017

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

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20 March 2017

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

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20 March 2017

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

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20 March 2017

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1

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20 March 2017

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants [...]

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20 March 2017

U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

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20 March 2017

A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

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20 March 2017

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20 March 2017

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

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20 March 2017

Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication

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20 March 2017

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

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20 March 2017

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

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20 March 2017

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

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20 March 2017

Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors

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20 March 2017

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO

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The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy.

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Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections

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29 September 2017

Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase

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Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors

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Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication

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Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

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What can be Expected from Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) in the Treatment of Human Immunodeficiency Virus Type 1 (HIV-1) Infections?

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PROCHECK: a program to check the stereochemical quality of protein structures

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Crystals of HIV-1 Reverse Transcriptase Diffracting to 2·2 Å Resolution

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Identifiers

10.1073/PNAS.94.8.3984

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2 November 2019

1997PNAS...94.3984E

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2 November 2019

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