Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1 (Q27729365)

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20 October 2019

title

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1 (English)

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20 October 2019

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1

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20 October 2019

Jonathan Friedman

6

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20 October 2019

author name string

J Jäger

2

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20 October 2019

J Wang

3

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20 October 2019

L A Kohlstaedt

4

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20 October 2019

A J Chirino

5

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20 October 2019

P A Rice

7

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20 October 2019

T A Steitz

8

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20 October 2019

language of work or name

English

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publication date

1 April 1994

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Proceedings of the National Academy of Sciences of the United States of America

20 October 2019

published in

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20 October 2019

volume

91

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20 October 2019

issue

9

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20 October 2019

page(s)

3911-3915

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 October 2019

cites work

1 reference

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A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

20 March 2017

1 reference

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Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase

20 March 2017

1 reference

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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

20 March 2017

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A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

20 March 2017

1 reference

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Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture

20 March 2017

1 reference

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Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors

20 March 2017

1 reference

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Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication

20 March 2017

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Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

20 March 2017

1 reference

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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

20 March 2017

1 reference

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Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity

20 March 2017

1 reference

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Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

20 March 2017

1 reference

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A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site

20 March 2017

1 reference

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Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

20 March 2017

1 reference

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Molecular targets for AIDS therapy

20 March 2017

1 reference

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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

20 March 2017

1 reference

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Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors

20 March 2017

1 reference

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2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri

20 March 2017

1 reference

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In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase

20 March 2017

1 reference

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3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

20 March 2017

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

20 March 2017

1 reference

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

7 April 2017

1 reference

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Slow-cooling protocols for crystallographic refinement by simulated annealing

7 April 2017

1 reference

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Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity

7 April 2017

1 reference

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Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template

29 September 2017

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Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assay

29 September 2017

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Amino acid substitutions in HIV-1 reverse transcriptase with corresponding residues from HIV-2. Effect on kinetic constants and inhibition by non-nucleoside analogs.

29 September 2017

1 reference

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HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase

2 June 2018

1 reference

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Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors

2 June 2018

1 reference

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Non-nucleoside inhibitors of HIV-1 reverse transcriptase: molecular modeling and X-ray structure investigations

2 June 2018

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Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase

2 June 2018

1 reference

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SQUASH - combining constraints for macromolecular phase refinement and extension

2 June 2018

1 reference

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Structural invariants in protein folding

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7513427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.91.9.3911

2 references

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20 October 2019

ADS bibcode

1994PNAS...91.3911S

0 references

1 reference

2 references

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20 October 2019

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