Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L (Q27684386)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Chudi O Ndubaku

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Brad E Sleebs

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Brian J. Smith

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

David C Huang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Philippe Bergeron

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Edna F Choo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Kevin Lau

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Danette Dudley

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Paul Gibbons

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Carl S Rye

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

George Nikolakopoulos

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Chinh Bui

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Sanji Kulasegaram

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Wilhelmus J A Kersten

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Peter E Czabotar

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Peter M Colman

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jonathan B Baell

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Keith G Watson

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Lisa Hasvold

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Zhi-Fu Tao

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Le Wang

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Andrew J Souers

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Steven W Elmore

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

John A Flygare

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Wayne J Fairbrother

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Guillaume Lessene

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

publication date

21 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

ACS Medicinal Chemistry Letters

20 March 2020

published in

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

662-667

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

Structure-guided design of a selective BCL-X(L) inhibitor

20 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Testicular degeneration in Bclw-deficient mice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Targeting the extrinsic apoptosis signaling pathway for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Bcl-2 family proteins as therapeutic targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

New insights into apoptosis signaling by Apo2L/TRAIL.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Small-molecule pan-IAP antagonists: a patent review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

BCL-2 family antagonists for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Programmed anuclear cell death delimits platelet life span.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Mcl-1 deficiency results in peri-implantation embryonic lethality

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Bcl-2 family proteins are essential for platelet survival.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060937

27 November 2018

Identifiers

DOI

10.1021/ML500030P

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24944740%20AND%20SRC:MED&resulttype=core&format=json