Structure-guided design of a selective BCL-X(L) inhibitor (Q27684453)

17

0 references

author name string

Guillaume Lessene

1

0 references

Peter E Czabotar

2

0 references

Kerry Zobel

4

0 references

Kym N Lowes

5

0 references

Jerry M Adams

6

0 references

Jonathan B Baell

7

0 references

Peter M Colman

8

0 references

Kurt Deshayes

9

0 references

Wayne J Fairbrother

10

0 references

John A Flygare

11

0 references

Paul Gibbons

12

0 references

Wilhelmus J A Kersten

13

0 references

Sanji Kulasegaram

14

0 references

Rebecca M Moss

15

0 references

John P Parisot

16

0 references

Ian P Street

18

0 references

Hong Yang

19

0 references

David C S Huang

20

0 references

Keith G Watson

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21

0 references

publication date

June 2013

0 references

published in

Nature Chemical Biology

0 references

volume

9

0 references

page(s)

390-7

0 references

issue

6

0 references

cites work

1 reference

12 December 2020

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

1 reference

12 December 2020

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

1 reference

12 December 2020

BCL-2 family antagonists for cancer therapy

1 reference

12 December 2020

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

Bcl-2 family proteins as therapeutic targets

1 reference

12 December 2020

Integration, scaling, space-group assignment and post-refinement

1 reference

12 December 2020

Structural insights into the degradation of Mcl-1 induced by BH3 domains

1 reference

12 December 2020

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

12 December 2020

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

12 December 2020

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

1 reference

12 December 2020

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

1 reference

12 December 2020

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

1 reference

12 December 2020

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

1 reference

12 December 2020

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

12 December 2020

Bcl-2 family proteins are essential for platelet survival.

1 reference

12 December 2020

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

1 reference

12 December 2020

The landscape of somatic copy-number alteration across human cancers

1 reference

12 December 2020

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

12 December 2020

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

12 December 2020

Structural biology of the Bcl-2 family of proteins

1 reference

12 December 2020

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

1 reference

12 December 2020

Structural plasticity underpins promiscuous binding of the prosurvival protein A1

1 reference

12 December 2020

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

1 reference

12 December 2020

Protein-protein interaction inhibitors get into the groove

1 reference

12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

12 December 2020

Programmed anuclear cell death delimits platelet life span.

1 reference

12 December 2020

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

12 December 2020

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

12 December 2020

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

1 reference

12 December 2020

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

1 reference

12 December 2020

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

12 December 2020

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

1 reference

12 December 2020

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

1 reference

12 December 2020

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

1 reference

12 December 2020

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

1 reference

12 December 2020

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

1 reference

12 December 2020

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

1 reference

12 December 2020

Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

1 reference

12 December 2020

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

1 reference

12 December 2020

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

1 reference

12 December 2020

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

1 reference

12 December 2020

Coot: model-building tools for molecular graphics

1 reference

12 December 2020

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

1 reference

12 December 2020

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

12 December 2020

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

12 December 2020

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

1 reference

12 December 2020

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

1 reference

12 December 2020

1 reference

12 December 2020

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

12 December 2020

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

12 December 2020

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

1 reference

12 December 2020

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1246

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1246

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

867334

1044425895

0 references

867334

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference