Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development (Q27684199)

2

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Giacomo Pizzolato

3

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Allen Lovey

4

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Qingjie Ding

5

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Nan Jiang

6

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Jin-Jun Liu

7

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Chunlin Zhao

8

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Kelli Glenn

9

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Yang Wen

10

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Christian Tovar

11

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Kathryn Packman

12

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Lyubomir Vassilev

13

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Bradford Graves

ACS Medicinal Chemistry Letters

14

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language of work or name

English

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publication date

9 May 2013

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published in

1 reference

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models

Crossref

volume

4

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page(s)

466-9

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issue

5

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

Structure-based design of novel inhibitors of the MDM2-p53 interaction

20 March 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

20 March 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

Regulation of p53 stability by Mdm2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

p53, the cellular gatekeeper for growth and division

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

Functions of the MDM2 oncoprotein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

20 March 2017

1 reference

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The p53 pathway: positive and negative feedback loops

20 March 2017

1 reference

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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

7 April 2017

1 reference

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Recent advances in the therapeutic perspectives of Nutlin-3.

29 September 2017

1 reference

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Small-molecule inhibitors of the p53-MDM2 interaction

29 September 2017

1 reference

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Awakening guardian angels: drugging the p53 pathway

29 September 2017

1 reference

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MDM2 inhibitors for cancer therapy

29 September 2017

1 reference

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Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

29 September 2017

1 reference

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

29 September 2017

1 reference

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MDM2 is a central node in the p53 pathway: 12 years and counting

29 September 2017

1 reference

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

29 September 2017

1 reference

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29 September 2017

MDM2, an introduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

Regulation of p53 stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145

p53 and human cancer: the first ten thousand mutations.

29 September 2017

1 reference

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29 September 2017

Identifiers

DOI

10.1021/ML4000657

1 reference

release_fnzukap4lzegzojx2aldkwy3pu

1648199

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fnzukap4lzegzojx2aldkwy3pu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1648199

1 reference

1 reference

1 reference