Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation (Q27681074)

24 June 2017

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation (English)

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24 June 2017

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7

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Marc Delarue

10

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Pierre-Jean Corringer

9

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Jean-Pierre Changeux

8

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Azadeh Shahsavar

object named as

Azadeh Shahsavar

2

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author name string

Ludovic Sauguet

1

1 reference

24 June 2017

Frédéric Poitevin

3

1 reference

24 June 2017

Christèle Huon

4

1 reference

24 June 2017

Anaïs Menny

5

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24 June 2017

Àkos Nemecz

6

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24 June 2017

Ahmed Haouz

7

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24 June 2017

Pierre-Jean Corringer

9

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24 June 2017

language of work or name

English

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publication date

23 December 2013

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Proceedings of the National Academy of Sciences of the United States of America

24 June 2017

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24 June 2017

111

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24 June 2017

3

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24 June 2017

966-971

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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

24 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

A locally closed conformation of a bacterial pentameric proton-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Principles of activation and permeation in an anion-selective Cys-loop receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

A gating mechanism of pentameric ligand-gated ion channels

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

A new era of GPCR structural and chemical biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Pore opening and closing of a pentameric ligand-gated ion channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Entropic mechanism of large fluctuation in allosteric transition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Ion channel gating: a first-passage time analysis of the Kramers type

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Low-resolution refinement tools in REFMAC5.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Desensitization mechanism in prokaryotic ligand-gated ion channel

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

The α1K276E startle disease mutation reveals multiple intermediate states in the gating of glycine receptors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314997111

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314997111

Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314997111

Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314997111

Computing free energy of a large-scale allosteric transition in adenylate kinase using all atom explicit solvent simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314997111

50 years of allosteric interactions: the twists and turns of the models

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Coarse-grained and all-atom modeling of structural states and transitions in hemoglobin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Predicting order of conformational changes during protein conformational transitions using an interpolated elastic network model

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3903189

Protein structural change upon ligand binding: linear response theory

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24367074

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thinking in cycles: MWC is a good model for acetylcholine receptor-channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24367074

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1314997111

1 reference

OpenCitations bibliographic resource ID

24 June 2017

0 references

733311

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference