Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling (Q27680715)

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

GOA release 2020-03-11

author name string

Kelly J Collins

series ordinal

1

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Zhenyu Yuan

series ordinal

2

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Rhett A Kovall

series ordinal

3

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language of work or name

1 reference

7 January 2014

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published in

Structure

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volume

22

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issue

1

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page(s)

70-81

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cites work

1 reference

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20 March 2017

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RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

20 March 2017

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20 March 2017

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Thermodynamic and structural insights into CSL-DNA complexes

20 March 2017

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RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

20 March 2017

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RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2

20 March 2017

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Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Protein production by auto-induction in high density shaking cultures

20 March 2017

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20 March 2017

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20 March 2017

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The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2

20 March 2017

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Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

20 March 2017

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Signalling downstream of activated mammalian Notch

20 March 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

20 March 2017

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7 April 2017

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Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.

7 April 2017

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Targeting the Notch pathway: twists and turns on the road to rational therapeutics

29 September 2017

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Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth

29 September 2017

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Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes

29 September 2017

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Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.

29 September 2017

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Notch signaling in solid tumors.

29 September 2017

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Mechanistic insights into Notch receptor signaling from structural and biochemical studies

29 September 2017

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Reduced Notch signaling leads to renal cysts and papillary microadenomas

29 September 2017

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Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.

29 September 2017

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The Notch signaling pathway: transcriptional regulation at Notch target genes

29 September 2017

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The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

29 September 2017

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Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

29 September 2017

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Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

29 September 2017

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Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

29 September 2017

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Notch signaling and inherited disease syndromes

29 September 2017

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Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction

29 September 2017

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LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein

29 September 2017

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Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk

29 September 2017

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Heat capacity and entropy changes in processes involving proteins

29 September 2017

1 reference

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Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers

29 September 2017

1 reference

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Notch1 is essential for postimplantation development in mice.

2 June 2018

1 reference

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KyoT3, an isoform of murine FHL1, associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation

2 June 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

27 November 2018

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Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

27 November 2018

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Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24290140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2013.10.010

1 reference

2494630

2494630

1 reference

1 reference

1 reference